{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:06:09Z","timestamp":1755216369311,"version":"3.43.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Myeloablative conditioning (MAC) for acute myeloid leukemia (AML) improves disease control by reducing relapse risk but is associated with higher non\u2010relapse mortality (NRM). Reduced\u2010intensity conditioning (RIC) aims to minimize toxicity but raises concerns about higher relapse rates. This study evaluates the impact of RIC versus MAC in AML patients under 65\u2009years receiving GVHD prophylaxis with antithymocyte globulin, post\u2010transplant cyclophosphamide, and cyclosporine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 322 AML patients undergoing allogeneic HCT with uniform GVHD prophylaxis. Propensity score matching (PSM) was applied to adjust for baseline differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the matched cohort, 2\u2010year overall survival (OS) did not differ significantly between RIC and MAC recipients (64.4% vs. 66.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.56). Relapse\u2010free survival (RFS) at 2\u2009years was 65.0% for MAC and 52.7% for RIC (<jats:italic>p<\/jats:italic>\u2009=\u20090.20). Two\u2010year NRM was 19.4% for MAC and 19.1% for RIC (<jats:italic>p<\/jats:italic>\u2009=\u20090.84). Improved RFS was associated with non\u2010high\u2010risk DRI (HR: 0.39, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), whereas conditioning intensity had no significant effect (HR: 0.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.97). NRM was higher among patients with KPS\u2009&lt;\u200990 (HR: 3.63, <jats:italic>p<\/jats:italic>\u2009=\u20090.01), with no significant impact observed from conditioning intensity (HR: 1.44, <jats:italic>p<\/jats:italic>\u2009=\u20090.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a relatively younger cohort, conditioning intensity did not significantly impact survival, and MAC was not associated with increased NRM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14438","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:50:14Z","timestamp":1748479814000},"page":"251-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Conditioning Intensity on Survival in Adult Patients (&lt;\u200965\u2009Years) With Acute Myeloid Leukemia Receiving Antithymocyte Globulin and Post\u2010Transplantation Cyclophosphamide Based <scp>GVHD<\/scp> Prophylaxis"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-0642","authenticated-orcid":false,"given":"Ahmed","family":"Alnughmush","sequence":"first","affiliation":[{"name":"Hans Messner Allogeneic Blood and Marrow Transplant Program, Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Canada"},{"name":"Department of Hematology, Stem Cell Transplant and Cellular Therapy, Oncology Centre King Faisal Specialist Hospital and Research Centre  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruah","family":"Alyamany","sequence":"additional","affiliation":[{"name":"Hans Messner Allogeneic Blood and Marrow Transplant Program, Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Canada"},{"name":"Department of Hematology, Stem 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