{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:11:48Z","timestamp":1775034708542,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bendamustine\u2010rituximab (BR) has demonstrated efficacy and tolerability in the treatment of various indolent B\u2010cell lymphomas, but there is limited data regarding its outcomes in nodular lymphocyte predominant B\u2010cell (Hodgkin) lymphoma (NLPBL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, population\u2010based study included consecutive patients \u2265\u200918\u2009years old who received BR for NLPBL in Alberta, Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 23 patients with a median age of 39\u2009years (range 18\u201374) who received BR for treatment\u2010naive (<jats:italic>n<\/jats:italic>\u2009=\u200917) or relapsed\/refractory (<jats:italic>n<\/jats:italic>\u2009=\u20096) NLPBL. Advanced stage disease was present in 18 (78%), splenic involvement in 9 (39%), and bone marrow involvement in 8 (35%) patients. The response rate to BR was 100%, with a complete response in 78% and a partial response in 22%. After a median follow\u2010up of 4.3\u2009years (range 0.8\u20139.0), the 4\u2010year progression\u2010free survival and overall survival rates were 83% (95% CI: 55%\u201394%) and 87% (95% CI: 58%\u201397%) for all patients and 84% (95% CI: 50%\u201396%) and 91% (95% CI: 51%\u201399%) for recipients of first\u2010line BR, respectively. The safety profile was in keeping with the known toxicities of BR, with the most common adverse events consisting of neutropenia, rash, and infusion reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that BR is a promising treatment option for NLPBL, with a favorable efficacy and safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14443","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T21:29:50Z","timestamp":1748813390000},"page":"260-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Bendamustine\u2010Rituximab for Nodular Lymphocyte Predominant Hodgkin Lymphoma"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0299-6465","authenticated-orcid":false,"given":"Alexander","family":"Robin","sequence":"first","affiliation":[{"name":"Alberta Health Services and University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Owen","sequence":"additional","affiliation":[{"name":"Alberta Health Services and University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Perry","sequence":"additional","affiliation":[{"name":"Alberta Health Services and University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Street","sequence":"additional","affiliation":[{"name":"Alberta Health Services and University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Chua","sequence":"additional","affiliation":[{"name":"Alberta Health Services and University of Alberta  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Stewart","sequence":"additional","affiliation":[{"name":"Alberta Health Services and University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Puckrin","sequence":"additional","affiliation":[{"name":"Alberta Health Services and University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"issue":"11","key":"e_1_2_9_3_1","first-page":"3476","article-title":"Nodular Lymphocyte\u2010Predominant Hodgkin Lymphoma: Advances in Disease Biology, Risk Stratification, and Treatment","volume":"109","author":"Salvaris R. 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