{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:04:32Z","timestamp":1787785472121,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chimeric antigen receptor T\u2010cell therapy (CART) has replaced salvage immunochemotherapy followed by high\u2010dose chemotherapy and autologous stem cell transplantation (HDT\u2010ASCT) as the preferred second\u2010line treatment for early relapsed (&lt;\u200912\u2009months) large B\u2010cell lymphoma (LBCL). However, for patients with a late relapse (&gt;\u200912\u2009months), CART is inaccessible until third line. We analyzed 877 patients from the HemoBase registry (diagnosed 2005\u20132020) to assess differences in long\u2010term outcomes of early versus late relapse in second line. Early relapse occurred in 120\/654 patients (18%) who completed first\u2010line treatment, with 2\u2010 and 5\u2010year overall survival (OS) of 22% and 18%. Late relapse occurred in 70 patients (11%), showing slightly better 2\u2010year OS of 36% but similarly poor 5\u2010year OS of 20%. Only 13% of early and 16% of late relapsed patients completed HDT\u2010ASCT, achieving 5\u2010year OS of 71% and 49%, respectively. Most patients initiating salvage immunochemotherapy did not reach HDT\u2010ASCT and had dismal survival (5\u2010year OS 8% early, 18% late), comparable to HDT\u2010ASCT\u2010ineligible patients (10% early, 14% late). These real\u2010world data highlight poor outcomes with previous second\u2010line therapies and support alternative strategies like CART in second line for patients with both early relapsing (&lt;\u200912\u2009months) and late relapsing (&gt;\u200912\u2009months) LBCL.<\/jats:p>","DOI":"10.1111\/ejh.70003","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:58:36Z","timestamp":1752073116000},"page":"391-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patients With Relapsed Large B\u2010Cell Lymphoma After 12\u2009Months Have a Similarly Poor Prognosis to Those Relapsing Within 12\u2009Months"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4940-3321","authenticated-orcid":false,"given":"Hilde T.","family":"van der Gali\u00ebn","sequence":"first","affiliation":[{"name":"Department of Hematology, Frisius MC  Leeuwarden the Netherlands"},{"name":"Department of Hematology University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde A. 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