{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:58:55Z","timestamp":1784213935481,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This retrospective, single\u2010center study aims to compare the efficacy and safety of a reduced dose of post\u2010transplantation cyclophosphamide (PTCy) (60\u2009mg\/kg total dose) versus the standard dose (100\u2009mg\/kg total dose), both combined with tacrolimus, in adult patients undergoing allogeneic hematopoietic stem cell transplantation from HLA\u2010matched related or unrelated donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report clinical outcomes of 59 consecutive patients who received standard doses of PTCy and 48 with the new reduced dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neutrophil and platelet recovery occurred later in the standard\u2010dose group (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.01). The incidence of febrile neutropenia was higher in the standard\u2010dose group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). No significant differences were found in the incidence of acute cardiac events, early bacteremia, CMV reactivation within the first 100\u2009days post\u2010HSCT, or the development of hemorrhagic cystitis. There were no significant differences in the incidence of grade II\u2013IV and III\u2013IV acute GvHD, moderate\u2010to\u2010severe chronic GvHD, or in 20\u2010month overall survival and progression\u2010free survival (<jats:italic>p\u2009&gt;<\/jats:italic>\u20090<jats:italic>.<\/jats:italic>05). Non\u2010relapse mortality at 100\u2009days and at 1\u2009year was comparable between groups, as was 1\u2010year GVHD\u2010free\/relapse\u2010free and immunosuppression\u2010free survival (<jats:italic>p\u2009&gt;<\/jats:italic>\u20090<jats:italic>.<\/jats:italic>05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reduced doses of CyPT combined with a single immunosuppressive agent are emerging as a safe and effective alternative for adult patients undergoing allo\u2010HSCT from HLA\u2010matched donors. Our findings support that this approach preserves key clinical outcomes while potentially reducing acute hematological and infectious toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.70010","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T08:10:01Z","timestamp":1753258201000},"page":"413-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Standard Versus Reduced\u2010Doses of Post\u2010Transplant Cyclophosphamide in <scp>HLA<\/scp> Matched (10\/10) Peripheral Blood Stem Cell Transplantation"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-7410","authenticated-orcid":false,"given":"Sara","family":"Redondo","sequence":"first","affiliation":[{"name":"Hematology Department, Hospital de la Sant Creu i Sant Pau. IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes Universitat Aut\u00f3noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Garc\u00eda\u2010Cadenas","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Sant Creu i Sant Pau. IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes Universitat Aut\u00f3noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Esquirol","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Sant Creu i Sant Pau. IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes Universitat Aut\u00f3noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Iranzo","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Sant Creu i Sant Pau. IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes Universitat Aut\u00f3noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Arguello\u2010Tomas","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Sant Creu i Sant Pau. IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes Universitat Aut\u00f3noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Sant Creu i Sant Pau. IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes Universitat Aut\u00f3noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"O\u00f1ate","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Sant Creu i Sant Pau. 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