{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T15:14:10Z","timestamp":1765898050322,"version":"3.48.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In chronic lymphocytic leukemia (CLL), treatment initiation is deferred until clinical symptoms emerge, aiming to minimize treatment\u2010related burden and maintain health\u2010related quality\u2010of\u2010life (QoL). We examined gender differences in QoL among patients undergoing active surveillance versus targeted therapies. Participants completed the Functional Assessment of Cancer Therapy\u2010Leukemia (\n                    <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\n                    \u2010Leu) Questionnaire, and the score was derived from the\n                    <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\n                    \u2010General (\n                    <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\n                    \u2010G) and leukemia\u2010specific concerns (Leu\u2010Subscale). Comparisons between treatment groups were conducted using Student's\n                    <jats:italic>t<\/jats:italic>\n                    \u2010test, stratified by sex. Among 210 participants, 63 were under surveillance, 115 in treatment, and 32 post\u2010treatment. Among men, the surveillance group reported better physical well\u2010being (mean: 25.2 vs. 19.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), Leu\u2010Subscale (mean: 51.5 vs. 42.8,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), and FACT\u2010Leu (mean: 135.9 vs. 120.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) compared to the active treatment group. In contrast, women in surveillance reported lower social well\u2010being (mean: 18.9 vs. 22.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008); emotional well\u2010being (mean: 15.5 vs. 18.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003); FACT\u2010G (mean: 74.6 vs. 83.3,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009); and FACT\u2010Leu (mean: 116.7 vs. 128.3,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) compared to the active treatment. A significant interaction was observed between treatment group and sex in the emotional well\u2010being subscale. In conclusion, men in surveillance reported better overall QoL than those in active treatment, whereas women in active treatment experienced better overall QoL than those in surveillance. These findings highlight the importance of gender\u2010specific approaches to improve health\u2010related QoL in CLL care.\n                  <\/jats:p>","DOI":"10.1111\/ejh.70017","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:41:24Z","timestamp":1754030484000},"page":"465-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gender Disparities in Health\u2010Related Quality of Life in Patients With Chronic Lymphocytic Leukemia: Impact of Treatment Modality"],"prefix":"10.1111","volume":"115","author":[{"given":"Bushra","family":"Mahameed","sequence":"first","affiliation":[{"name":"School of Public Health, Faculty of Social Welfare and Health Sciences University of Haifa  Haifa Israel"},{"name":"Institute of Pathology, Maccabi Healthcare Services  Yokneam Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giora","family":"Sharf","sequence":"additional","affiliation":[{"name":"Halil Haor, Patients Organization  Netanya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Tadmor","sequence":"additional","affiliation":[{"name":"Hematology Unit Bnai Zion Medical Center  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geffen","family":"Kleinstern","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Social Welfare and Health Sciences University of Haifa  Haifa 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