{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:07:35Z","timestamp":1789276055159,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Waldenstr\u00f6m macroglobulinemia (WM) is an uncommon indolent B\u2010cell lymphoma driven by\n                    <jats:italic>MYD88<\/jats:italic>\n                    and\n                    <jats:italic>CXCR4<\/jats:italic>\n                    mutations. Although serum B\u2010cell maturation antigen (sBCMA) has been shown to be a prognostic and monitoring tool for multiple myeloma patients, it has not been evaluated among those with WM. We assessed sBCMA levels among 50 WM patients: 16 had received prior therapy, while 34 were treatment\u2010na\u00efve (TN), 19 of whom never went on to require therapy (smoldering [S]WM). Levels were higher among WM patients (median, 63.76\u2009ng\/mL) than healthy subjects (median, 35.24\u2009ng\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). TNWM patients who required therapy showed higher initial levels (median, 137.71\u2009ng\/mL) than those with SWM (median, 50.19\u2009ng\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002). sBCMA also correlated with disease status: levels decreased at best response (\u2265\u2009minimal response; median, 38.36\u2009ng\/mL) compared to baseline (median, 117.00\u2009ng\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0078) and increased among patients who developed progressive disease (median, 79.42\u2009ng\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0625). Baseline sBCMA levels positively correlated with \u03b22 microglobulin (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0193) and M\u2010protein (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0450), and negatively with hemoglobin (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0090) and albumin (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0016). Overall, these findings suggest sBCMA may serve as a biomarker for prognosis and monitoring for WM patients.\n                  <\/jats:p>","DOI":"10.1111\/ejh.70029","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:00:02Z","timestamp":1758085202000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum B\u2010Cell Maturation Antigen as a Biomarker for Predicting Outcomes and Monitoring Patients With Waldenstr\u00f6m Macroglobulinemia"],"prefix":"10.1111","volume":"116","author":[{"given":"Marissa\u2010Skye","family":"Goldwater","sequence":"first","affiliation":[{"name":"ONCOtracker  West Hollywood California USA"},{"name":"Institute for Myeloma &amp; Bone Cancer Research  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Moore","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research  West Hollywood California USA"},{"name":"Berenson Cancer Center  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Bujarski","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research  West Hollywood California USA"},{"name":"Berenson Cancer Center  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Danis","sequence":"additional","affiliation":[{"name":"Berenson Cancer Center  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakir","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Behare","sequence":"additional","affiliation":[{"name":"Institute for Myeloma &amp; Bone Cancer Research  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Swift","sequence":"additional","affiliation":[{"name":"Berenson Cancer Center  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsiye","family":"Emamy\u2010Sadr","sequence":"additional","affiliation":[{"name":"Berenson Cancer Center  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Eades","sequence":"additional","affiliation":[{"name":"Berenson Cancer Center  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Berenson","sequence":"additional","affiliation":[{"name":"ONCOtracker  West Hollywood California USA"},{"name":"Institute for Myeloma &amp; Bone Cancer Research  West Hollywood California USA"},{"name":"Berenson Cancer Center  West Hollywood California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.017251"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018022962"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200710"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620711410096"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01821"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15082240"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-017-0538-x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1448269"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09241.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.150896"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2022.04.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3552"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03285-y"},{"key":"e_1_2_11_15_1","article-title":"Symptomatic Hypoalbuminemia as an Indication for Treatment of Waldenstr\u00f6m Macroglobulinemia: A Case Report and Review of the Literature","author":"Larsen J. 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