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In this retrospective real\u2010life multicenter Italian study, we investigated the safety and efficacy of momelotinib in a cohort of 39 consecutive MF patients, regardless of prior therapy. The median duration of treatment was 7\u2009months, and the overall response rate was 56% in transfusion\u2010dependent patients and 46% in the transfusion\u2010independent group. At 24\u2009weeks of treatment, a hemoglobin increase &gt;\u20091.5\u2009g\/dL was observed in 26% of patients, and constitutional symptom improvement was reported in 51% of cases, with a spleen volume reduction &gt;\u200935% in 28%. Therapy discontinuation occurred in 18% of patients, with only one leukemia progression and three deaths during follow\u2010up. The safety profile was similar to that reported in clinical trials, with most toxicities of grade I\u2010II. In conclusion, our real\u2010life results support the use of momelotinib as an effective and safe therapeutic option for heavily pre\u2010treated, cytopenic MF patients in real\u2010world clinical practice.<\/jats:p>","DOI":"10.1111\/ejh.70034","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:06:06Z","timestamp":1758006366000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Momelotinib in Myelofibrosis Patients: Results From a Multicenter Study"],"prefix":"10.1111","volume":"116","author":[{"given":"Maria Carmen","family":"Martorelli","sequence":"first","affiliation":[{"name":"Hematology and Transplant Center University Hospital \u201cSan Giovanni di Dio e Ruggi d'Aragona\u201d  Salerno 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