{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T08:07:47Z","timestamp":1786867667368,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Frailty is a key consideration in determining whether a patient is robust enough for CAR T\u2010cell therapy; however, it should not represent a barrier to treatment. Our study aimed to describe the extent of research concerning frailty in haematology adult and paediatric patients being considered for CAR T\u2010cell therapy and its potential impact on their eligibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following the Joanna Briggs Institute guidelines, we adopted a scoping review methodology. Our search was conducted across the databases CINAHL, Cochrane, Embase, Medline, PubMed, Google Scholar,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      , clinical trials register.eu, and euclinicaltrials.eu for studies published from 2017 to March 2nd 2024. Studies were screened by independent teams of reviewers using the web application Rayyan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our review included 12 studies, with varied study designs. No study in a pediatric CAR T\u2010cell setting was found. A wide variation in assessing frailty before CAR T\u2010cell therapy was evident, with ECOG being the most frequently used assessment tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An appropriate frailty assessment before CAR T\u2010cell therapy promotes the productive use of resources and proper patient selection. Using a geriatric assessment and incorporating an assessment tool such as the CAR HEMATOTOX has the potential for assessing frail CAR T\u2010cell therapy patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70037","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:36:35Z","timestamp":1758872195000},"page":"4-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of Frailty in Assessing Eligibility for\n                    <scp>CAR<\/scp>\n                    T\u2010Cell Therapy in Haematology"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-4901","authenticated-orcid":false,"given":"Jennifer","family":"Clesham","sequence":"first","affiliation":[{"name":"Haematology Clinical Nurse Specialist in University Hospital Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0608-7471","authenticated-orcid":false,"given":"Joan","family":"McGrory","sequence":"additional","affiliation":[{"name":"Haematology Clinical Nurse Specialist in University Hospital Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0710-654X","authenticated-orcid":false,"given":"Aoife","family":"Bannon","sequence":"additional","affiliation":[{"name":"Haematology Clinical Nurse Specialist in University Hospital Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9435-9158","authenticated-orcid":false,"given":"Deirbhle","family":"Cox","sequence":"additional","affiliation":[{"name":"Haematology Clinical Nurse Specialist in University Hospital Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-6276","authenticated-orcid":false,"given":"Maura","family":"Dowling","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery University of Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020228"},{"key":"e_1_2_9_3_1","first-page":"2452","article-title":"How I Approach Optimization of Patients at Risk of Cardiac and Pulmonary Complications After CAR T\u2010Cell Therapy","volume":"141","author":"Gutierrez C.","year":"2023","journal-title":"Blood"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013365.pub2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-746420"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.243246"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-94353-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00060-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu540"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0051-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12514"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.10.066"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00456-y"},{"issue":"7","key":"e_1_2_9_16_1","first-page":"467","article-title":"Chapter\u00a011: Scoping Reviews","volume":"169","author":"Peters M. D.","year":"2020","journal-title":"JBI Manual for Evidence Synthesis"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2024.101734"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"346","article-title":"Comprehensive Geriatric Assessment to Predict Outcomes in Older Patients Received CAR\u2010T Cell Therapy","volume":"56","author":"Montoro\u2010Lorite M.","year":"2021","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19302"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184671"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-189154"},{"issue":"3","key":"e_1_2_9_23_1","first-page":"S195","article-title":"Impact of Frailty on Outcomes After CAR T\u2010Cell Therapy for Patients With Relapsed\/Refractory Multiple Myeloma","volume":"30","author":"Davis J. A.","year":"2023","journal-title":"Transplantation and Cellular Therapy"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18810"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.12052"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.05.015"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-129532"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.12.003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00184-7"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.245803"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27369"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2022.2021218"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2022.10.016"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010127"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-009349"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(22)00172-6"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010543"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004475"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025910"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01465-x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2025.104648"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0075-2"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2388-9"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13610"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.02.005"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34557"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2014.967174"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40900-020-00230-5"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174320"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:26:39Z","timestamp":1764750399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ejh.70037"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70037","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"2025-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}