{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:09:44Z","timestamp":1790640584606,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chimeric antigen receptor (CAR) T\u2010cell therapy is a well\u2010established approach for refractory hematological malignancies. Cytokine release syndrome (CRS) and immune effector cell\u2010associated neurotoxicity syndrome (ICANS) remain a major concern of CAR T\u2010cell therapy, particularly in refractory cases where therapeutic options are limited. We report a case of severe, steroid\u2010refractory ICANS following axicabtagene ciloleucel infusion. Despite treatment with anakinra, high\u2010dose methylprednisolone, and intrathecal chemotherapy, no clinical improvement was observed. Only after dasatinib introduction as a fourth\u2010line treatment did the patient show an improvement in ICANS, suggesting the potential benefit of this agent in the management of refractory neurotoxicity after CAR T\u2010cells.<\/jats:p>","DOI":"10.1111\/ejh.70038","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T02:48:30Z","timestamp":1757990910000},"page":"610-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of Dasatinib for the Treatment of Refractory Immune Effector Cell\u2010Associated Neurotoxicity Syndrome After Axicabtagene Ciloleucel Infusion: A Case Report"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0880-5356","authenticated-orcid":false,"given":"Jaime","family":"Llata\u2010Ortega","sequence":"first","affiliation":[{"name":"Pharmacy Department Vall d'Hebron University Hospital  Barcelona Spain"},{"name":"Basic, 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