{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:39:34Z","timestamp":1792575574668,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Baseline cardiovascular (CV) risk stratification is an essential component in managing patients undergoing potential cardiotoxic anticancer therapies. Chimeric antigen receptor (CAR)\u2010T cell therapy, a groundbreaking treatment for hematologic malignancies, is associated with a non\u2010negligible risk of cardiovascular adverse events (CVAE). This study aimed to identify predictors of CAR\u2010T cell\u2010related CVAE and to develop a corresponding risk stratification score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a meta\u2010analysis of studies comparing baseline clinical, biomarker, echocardiographic findings, and pharmaceutical treatments between patients who developed CAR\u2010T cell\u2010related CVAE and those who did not. We subsequently used the pooled relative risks (RR) of significant predictors to construct a risk stratification score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 12 relevant studies encompassing a total of 1354 patients with haematologic malignancies, the majority of which were treated with CD19\u2010directed CAR\u2010T cell therapy, of whom 228 (16.8%) developed CVAE. Significant predictors of CAR\u2010T cell\u2010related CVAE included coronary artery disease [RR\u2009=\u20092.27 (95% confidence interval, 1.46\u20133.51)], hyperlipidaemia [1.57 (1.14\u20132.15)], diabetes [1.59 (1.13\u20132.24)], hypertension [1.45 (1.18\u20131.77)], atrial fibrillation [2.42 (1.51\u20133.88)], heart failure [2.74 (1.62\u20134.61)], and smoking [1.40 (1.10\u20131.79)]. The resulting risk prediction score, incorporating the above seven factors, named CART\u20107, ranges from 0 to 33, with a score of 0\u20138 indicating low risk, 9\u201317 moderate risk, 18\u201325 high risk, and 26\u201333 very high risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Seven baseline CV conditions were significantly associated with CAR\u2010T cell\u2010related CVAE. Further validation of the resulting CART\u20107 score is warranted to support its clinical use in baseline CV risk stratification for patients undergoing CAR\u2010T cell therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70040","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:40:33Z","timestamp":1759905633000},"page":"54-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictive Factors and Baseline Risk Stratification for\n                    <scp>CAR<\/scp>\n                    \u2010T Cell Therapy\u2010Related Cardiovascular Toxicity"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-3447","authenticated-orcid":false,"given":"Dimitrios","family":"Farmakis","sequence":"first","affiliation":[{"name":"Department of Cardiology Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos I.","family":"Karampinos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Cordoba","sequence":"additional","affiliation":[{"name":"Department of Haematology Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS\u2010FJD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"L\u00f3pez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Cardiology La Paz University Hospital, idiPAZ Research Institute  Madrid Spain"},{"name":"Department of Cardiology University Hospital Quir\u03ccnsalud  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0306-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2020.02.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.02.070"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.08.044"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","unstructured":"Erratum to: 2022 ESC Guidelines on Cardio\u2010Oncology Developed in Collaboration With the European Hematology Association (EHA) the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio\u2010Oncology Society (IC\u2010OS): Developed by the Task Force on Cardio\u2010Oncology of the European Society of Cardiology (ESC). 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