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Remissions in CNS and other organs began to be reported and are continuously observed to present. With resistance to one BCR::ABL1 tyrosine kinase inhibitor and sensitivity to a dual BCR::ABL1\/SRC inhibitor recognized, we undertook a retrospective observational study of all reported patients with EML given dasatinib\u2009\u00b1\u2009routine therapies used over 50\u2009years. We elicited remission durations from authors. One hundred and sixty\u2010three patients (150 Ph\u2032+, 13 Ph\u2032\u2212 negative leukemias) received dasatinib\u2009\u00b1\u2009conventional EML treatments. All but six cases reported disappearance of EML involvement, documented by MRI, CSF, PET\/CT in 10, and autopsy in 2. To date, 36 EML remissions have lasted 2+\u201311+\u2009years (15\u2009&gt;\u20094\u2009years). Thirty\u2010four of the responding patients had post\u2010dasatinib transplants and 3 CAR\u2010T therapy. The tyrosine kinase inhibitor overexpressed in our prior RNAseq studies of EML tissue was LCK, a SRC kinase target of dasatinib known to be present in CNS, nerves, and some cancers. We present published data to support LCK as one possible tissue target in EML. As there has never been any durably effective treatment for EML, these observations merit prospective trials to validate the observed success of dasatinib and determine the role of additional therapies including cellular therapies. Dasatinib is a potentially practice\u2010changing targeted therapy for EML. Finding and eradicating EML could increase the possibility of lengthy disease\u2010free survival.<\/jats:p>","DOI":"10.1111\/ejh.70051","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:00:12Z","timestamp":1765371612000},"page":"302-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dasatinib Produces Lengthy Remissions of Extramedullary Leukemia: A Retrospective Observational Study"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-4501","authenticated-orcid":false,"given":"I.","family":"Cunningham","sequence":"first","affiliation":[{"name":"Division of Hematology Oncology Columbia University Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-4836","authenticated-orcid":false,"given":"R. 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