{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:55:17Z","timestamp":1767894917066,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Several adaptations have been reported since the introduction of posttransplant cyclophosphamide (PTCy)\u2010based haploidentical transplantation (Haplo). This single\u2010center observational study compared the outcomes of PTCy\u2010based Haplo with MMF at 30\u2009mg\/kg to a concurrent cohort of unrelated donors (URD) who received mainly ATG at 6\u2009mg\/kg proximal to transplantation. We included 174 patients (median follow\u2010up: 33\u2009months). Two\u2010year OS for Haplo was 55%, which was not significantly lower than that for URD (67%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.22). Two\u2010year RFS was 53% for Haplo, compared to 60% for URD (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.31). Two\u2010year GRFS was significantly worse for Haplo (24%) compared to URD (40%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Relapse rates were similar (16% for Haplo and 21% for URD,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.66), but non\u2010relapse mortality was significantly higher for Haplo (31%) versus 19% for URD (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). GVHD outcomes did not differ in univariable analyses. In multivariable analyses, there was a trend toward higher grades III\u2013IV aGVHD (HR\u2009=\u20092.01,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.08) and moderate to severe cGVHD (HR\u2009=\u20091.80,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05). In summary, we have shown that MMF at 30\u2009mg\/kg in Haplo transplants achieved similar PFS and OS compared to ATG\u2010based URD. However, GRFS was lower, likely due to a significantly higher NRM associated with a trend towards higher moderate to severe cGVHD.\n                  <\/jats:p>","DOI":"10.1111\/ejh.70054","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:42:12Z","timestamp":1760960532000},"page":"142-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Posttransplant Cyclophosphamide\u2010Based Haploidentical Transplantation, With\n                    <scp>MMF<\/scp>\n                    30\u2009mg\/kg, Compared With Unrelated Donor Transplantation With\n                    <scp>ATG<\/scp>\n                    6\u2009mg\/kg, With Bone Marrow or Peripheral Blood Stem Cell Grafts"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-1945","authenticated-orcid":false,"given":"Leonardo Javier","family":"Arcuri","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein Academic Research Organization  Sao Paulo Brazil"},{"name":"Bone Marrow Transplantation Department Instituto Nacional de Cancer  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Pereira","family":"Lermontov","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Department Instituto Nacional de Cancer  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla de Oliveira","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Department Instituto Nacional de Cancer  Rio de Janeiro Brazil"},{"name":"Bone Marrow Transplantation Department Complexo Hospitalar de Niteroi  Niteroi Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.08.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.01.031"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.93"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.06.019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.06.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.01.076"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.09.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011281"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.07.024"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102024\u2010203105"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.07.037"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.01.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9736564"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(15)00462\u20103"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:10:21Z","timestamp":1767874221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/ejh.70054"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70054","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"assertion":[{"value":"2025-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}