{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:30:51Z","timestamp":1764750651335,"version":"3.46.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Previous studies investigating the role of\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations in chronic phase MPN have yielded inconsistent results. As such, the clinical relevance of these mutations remains to be elucidated. We report a case of a 67\u2010year\u2010old woman with a leukemic transformation of a post\u2010polycythaemia vera myelofibrosis (post\u2010PV MF) that culminated in the rare development of a myeloid sarcoma. During a 4\u2010year follow\u2010up, the patient had a stable\n                    <jats:italic>JAK2<\/jats:italic>\n                    Val617Phe and\n                    <jats:italic>NFE2<\/jats:italic>\n                    mutation (Variant Allele Frequencies (VAF's) 85%\u201387% and 43%\u201350%, respectively) and low\u2010burden\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation (VAF 2%\u20137%) in blood and bone marrow. Despite having a low\u2010risk post\u2010PV MF, the patient soon presented with an aggressive lytic lesion in the humerus, which proved to be a myeloid sarcoma. The sarcoma was positive for\n                    <jats:italic>JAK2<\/jats:italic>\n                    Val617Phe but, interestingly, was also highly enriched for the\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation (VAF 81%), implicating a role of the\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation in the leukemic progression. This case provides molecular evidence that a\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation, even at a low burden, may contribute to leukemic progression of a chronic phase myeloproliferative neoplasm (MPN). These observations increase our understanding of the pathophysiologic behavior of\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations and underscore the importance of further causal research towards the clinical implications of these mutations in chronic phase MPN.\n                  <\/jats:p>","DOI":"10.1111\/ejh.70055","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T23:13:54Z","timestamp":1761261234000},"page":"93-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clonal Progression and Leukemic Transformation of a\n                    <i>TP53<\/i>\n                    Mutated Post\u2010Polycythaemia Vera Myelofibrosis"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-3781","authenticated-orcid":false,"given":"Isidor","family":"Minovi\u0107","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-9638","authenticated-orcid":false,"given":"Bart","family":"Koopman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris J. W.","family":"Ploegmakers","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise M. J.","family":"van der Logt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"},{"name":"Department of Molecular Diagnostics Pathology Friesland  Leeuwarden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjen H. G.","family":"Cleven","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk","family":"van der Veen","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjan","family":"Buijs","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 B.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Ammatuna","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Groningen, University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.169"},{"volume-title":"Haematolymphoid Tumours Part A","year":"2024","author":"WHO Classification of Tumours Editorial Board","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01886-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-09-875047"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.230"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27609"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102021\u2010152622"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:26:43Z","timestamp":1764750403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ejh.70055"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70055","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"type":"print","value":"0902-4441"},{"type":"electronic","value":"1600-0609"}],"subject":[],"published":{"date-parts":[[2025,10,23]]},"assertion":[{"value":"2025-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}