{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:45:23Z","timestamp":1791895523092,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>BV\u2009+\u2009AVD is increasingly used for frontline treatment of stage III\/IV cHL. Young adults and adults (Ya&amp;A) were the most common patients treated with BV\u2009+\u2009AVD in clinical trials but have not been studied in non\u2010trial settings. We conducted a real\u2010life study in secondary and tertiary cancer centers to evaluate the PFS in 18\u201359\u2009years aged patients who were scheduled to receive six BV\u2009+\u2009AVD for newly diagnosed advanced stage cHL. This is the largest cohort of Ya&amp;A reported to date including 150 patients from four clinical institutions in Southern Italy, all of which employed structured supportive care programs for HL. Fifty patients (30%) had at least one ECHELON\u20101 ineligibility criterion, including comorbidities and\/or adverse performance status. All 150 patients underwent BV\u2009+\u2009AVD with a median relative dose intensity of 100% (dose reduction and\/or discontinuation \u2265\u200915%, in 11% of them). At end\u2010of\u2010treatment (EoT) FDG\u2010PET, 93% (140\/147) of patients (three did not undergo EoT FDG\u2010PET due to early grade 5 toxicity) achieved a complete response (95% CI, 88.1\u201396.8). Altogether, four patients (2.7%) received consolidation radiotherapy of residual nodal masses with a Deauville score of 4. Grade \u2265\u20092 peripheral neuropathy, cardiotoxicity, and febrile neutropenia were reported by 13%, 7%, and 3% of patients, respectively. With a 24\u2009month median follow\u2010up, PFS in the entire analyzed population was 91% (95% CI, 0.864\u20130.958). In Ya&amp;A with high\u2010risk cHL, our data suggest that a BV\u2010driven strategy (without bleomycin and consolidation radiotherapy) is an effective up\u2010front option in oncologic centers specialized in HL care, improving the rate of durable complete remission in routine clinical practice.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT06857500\n                  <\/jats:p>","DOI":"10.1111\/ejh.70060","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T02:29:31Z","timestamp":1762482571000},"page":"174-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Brentuximab Vedotin With Adriamycin, Vinblastine, and Dacarbazine for Patients Aged 18\u201359\u2009Years With Untreated Advanced Stage Classical Hodgkin Lymphoma: The Largest Real\u2010Life Series From Southern Italy Cancer Centers"],"prefix":"10.1111","volume":"116","author":[{"given":"Marco","family":"Picardi","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5975-9388","authenticated-orcid":false,"given":"Annamaria","family":"Vincenzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples 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University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Mainolfi","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Fonti","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Del Vecchio","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Trastulli","sequence":"additional","affiliation":[{"name":"Hematology Unit Antonio Cardarelli Hospital of National Importance  Naples 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