{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:07:03Z","timestamp":1791245223788,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Identifying patients with a higher risk of recidivate\/refractory Hodgkin lymphoma (R\/R HL) is a challenge that needs to be addressed. The International Prognostic System (IPS) identifies patients with a poor prognosis in advanced stages, although its relevance has decreased due to advancements in modern treatment. The interim PET\u20102 scan after two chemotherapy cycles is now considered the most crucial prognostic tool, but it is only available after treatment initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigate the role of clinical and inflammatory indices associated with clinical data in 212 HL patients, focusing on peripheral blood ratios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During follow\u2010up, after a median of 60\u2009months [3\u2013213], 157 patients (74.1%) were in complete remission, and 55 were classified as R\/R. SII (platelets\u2009\u00d7\u2009neutrophils\/lymphocytes) \u2265\u2009270, IgM &lt;\u200950\u2009mg\/dL, male gender, and extranodal localization correlate with higher relapse and refractory rates. Assigning one point to each variable, a new prognostic score (ME\u2010IPS) was developed, recognizing three risk classes. A total of 135 (63.7%) patients belonged to the low\u2010risk class (0\u20131 points), 55 (25.9%) to intermediate (2 points), and 22 (10.4%) to high (3\u20134 points). The median PFS for the three groups was statistically different (not achieved vs. 89 vs. 8.8\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a 5\u2010year cut\u2010off of 83%, 67%, and 27% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). ME\u2010IPS, validated against the traditional IPS, performs better in identifying high\u2010risk patients with data collected at diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining the ME\u2010IPS model with PET\u20102 may provide a more effective tool for HL prognosis, particularly in cases of advanced disease, and guide treatment decisions in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70066","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:15:13Z","timestamp":1763972113000},"page":"235-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hodgkin\u2010Inflammatory\u2010Based Model ME\u2010IPS Is a New Inflammatory\u2010Based Prognostic Model Calculated at Diagnosis: Results From a Real\u2010Life Study"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9510-4755","authenticated-orcid":false,"given":"Andrea","family":"Duminuco","sequence":"first","affiliation":[{"name":"Hematology With BMT Unit A.O.U. \u201cG. 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