{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T03:03:16Z","timestamp":1770865396278,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009457","name":"Region Sj\u00e6lland","doi-asserted-by":"publisher","award":["18\/17127"],"award-info":[{"award-number":["18\/17127"]}],"id":[{"id":"10.13039\/501100009457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020035","name":"A. P. M\u00f8llerske St\u00f8ttefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Prognostic models in Waldenstr\u00f6m's macroglobulinemia (WM) are typically static, baseline tools applied before treatment initiation and do not account for dynamic post\u2010treatment factors. We evaluated time to next treatment within 24\u2009months (TTNT24), as a prognostic marker in symptomatic patients, and time to lymphoma treatment within 24\u2009months (TTLT24) in initially observed asymptomatic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this observational cohort study, patients diagnosed with lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinemia (LPL\/WM) in Region Zealand from 2000 to 2023 were identified using Danish national registries and health records. TTNT24 was defined as initiation of second\u2010line treatment within 24\u2009months of first\u2010line therapy. TTLT24 was defined as lymphoma\u2010directed treatment initiated within 24\u2009months of diagnosis in initially asymptomatic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 526 LPL\/WM patients, 218 symptomatic patients were evaluated for TTNT24 with 33 (15%) patients receiving second\u2010line treatment within 24\u2009months. TTNT24\u2010positive patients demonstrated inferior overall and lymphoma\u2010related survival compared to TTNT24\u2010negative patients. TTNT24 remained significant in multivariate analysis. Among 310 asymptomatic patients, TTLT24 was significantly associated only with lymphoma\u2010related survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TTNT24 and TTLT24 may serve as dynamic prognostic markers in real\u2010world LPL\/WM populations. Their relevance in the era of targeted therapies warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70073","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T04:31:22Z","timestamp":1764909082000},"page":"267-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time to Next Treatment Within 24\u2009Months (\n                    <scp>TTNT24<\/scp>\n                    ) as a Predictor of Survival in Lymphoplasmacytic Lymphoma\/Waldenstr\u00f6m Macroglobulinemia: A Population\u2010Based Observational Study"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5553-7269","authenticated-orcid":false,"given":"Lars","family":"Munksgaard","sequence":"first","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-8841","authenticated-orcid":false,"given":"Lars Moeller","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalie Sofie Eilsoe","family":"Munksgaard","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise Mette Rahbek","family":"Gjerdrum","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Pathology Zealand University Hospital  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50082"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01762-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0431-y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-174961"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02066"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010263"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000510"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001088"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2996"},{"key":"e_1_2_12_11_1","unstructured":"Q.Li H.Zhang Z.Chen et\u00a0al. 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