{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:30:07Z","timestamp":1775446207314,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients aged \u2265\u200970\u2009years with relapsed\/refractory multiple myeloma (RRMM) face unique challenges due to physiological changes and increased toxicity from treatments. Daratumumab\u2010based regimens have shown efficacy, but direct comparisons in elderly populations are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective study compared daratumumab, pomalidomide, and dexamethasone (DPd) to daratumumab, carfilzomib, and dexamethasone (DKd) in patients with RRMM aged \u2265\u200970\u2009years. The primary endpoint was progression\u2010free survival (PFS), with secondary endpoints including overall survival (OS) and response rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 150 patients (119 DPd, 31 DKd). Baseline characteristics were similar, but DPd had more lenalidomide\u2010refractory patients (90% vs. 74%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Overall response rates were comparable (DPd 77%, DKd 74.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8), but DKd had a significantly higher rate of deep responses (64.5% vs. 36%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Median PFS was 12\u2009months for DPd and 13\u2009months for DKd (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.6); median OS was 50\u2009months for DPd and 28\u2009months for DKd (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.2). Multivariate analysis identified poor performance status and high\u2010risk cytogenetics as adverse prognostic factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DPd and DKd showed similar efficacy for elderly RRMM patients, with DKd achieving deeper responses. Treatment decisions should consider individual patient factors rather than focusing solely on efficacy differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70077","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:31:18Z","timestamp":1768573878000},"page":"585-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Daratumumab Based Regimens in Patients With Relapsed\u2010Refractory Multiple Myeloma (\n                    <scp>RRMM<\/scp>\n                    ) Aged 70 and Above: A Multicenter Study"],"prefix":"10.1111","volume":"116","author":[{"given":"Razan","family":"Mansour","sequence":"first","affiliation":[{"name":"Division of Hematologic Malignancies &amp; Cellular Therapeutics University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly 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