{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:27:12Z","timestamp":1792466832297,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n Azacitidine (\n AZA<\/jats:styled-content>\n ) combined with venetoclax (\n VEN<\/jats:styled-content>\n ) as an outpatient treatment of unfit patients with acute myeloid leukemia (\n AML<\/jats:styled-content>\n ) has been infrequently investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We report on 65 elderly\n AML<\/jats:styled-content>\n patients: 35 patients received\n AZA<\/jats:styled-content>\n \u2009+\u2009\n VEN<\/jats:styled-content>\n as first\u2010line and 30 after progression on prior treatment with\n AZA<\/jats:styled-content>\n (R\/R group). Thirty\u2010eight patients were treated as outpatients, while 27 were hospitalized. The overall survival (\n OS<\/jats:styled-content>\n ) and event\u2010free survival (\n EFS<\/jats:styled-content>\n ) were calculated, and predictive factors were assessed using Cox regression models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Inpatients were slightly younger, with a median age of 72 versus 74\u2009years in outpatients (\n p<\/jats:italic>\n \u2009=\u20090.015). Median\n WBC<\/jats:styled-content>\n was higher in inpatients (median 7.3\u2009\u00d7\u200910\n 9<\/jats:sup>\n \/L vs. 2.9\u2009\u00d7\u200910\n 9<\/jats:sup>\n \/L,\n p<\/jats:italic>\n \u2009=\u20090.020). Median marrow blast count was 43% in inpatients versus 25.5% in outpatients (\n p<\/jats:italic>\n \u2009=\u20090.042). Treatment setting emerged as a key predictive factor for infection development during Cycle 1 in both univariate (\n p<\/jats:italic>\n \u2009=\u20090.016) and multivariate analysis (\n p<\/jats:italic>\n \u2009=\u20090.043), in the overall cohort. Inpatients had a significantly higher infection rate (81.4%) versus outpatients (44.7%,\n p<\/jats:italic>\n \u2009=\u20090.004). In R\/R group, 1\u2010year\n EFS<\/jats:styled-content>\n was 68% for outpatients versus 38% for inpatients (\n p<\/jats:italic>\n \u2009=\u20090.009). One\u2010year\n OS<\/jats:styled-content>\n was 77% in outpatients versus 38% in inpatients (\n p<\/jats:italic>\n \u2009=\u20090.052).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In most instances, outpatient administration of Cycle 1 of\n AZA<\/jats:styled-content>\n \u2009+\u2009\n VEN<\/jats:styled-content>\n should be preferred as a beneficial option.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ejh.70102","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:23:12Z","timestamp":1766362992000},"page":"402-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outpatient Versus Inpatient Azacitidine Plus Venetoclax Regimen in Elderly Acute Myeloid Leukemia: A Multicenter Retrospective Analysis"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7559-6095","authenticated-orcid":false,"given":"Deborah","family":"Kasmi","sequence":"first","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Bisegna","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Carmosino","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Scalzulli","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-2936","authenticated-orcid":false,"given":"Alessandro","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cenfra","sequence":"additional","affiliation":[{"name":"Department of Hematology Polo Universitario Pontino, S.M. Goretti Hospital Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Mecarocci","sequence":"additional","affiliation":[{"name":"Department of Hematology Polo Universitario Pontino, S.M. Goretti Hospital Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saveria","family":"Capria","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Minotti","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Martelli","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cartoni","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-8004","authenticated-orcid":false,"given":"Alessandro","family":"Pulsoni","sequence":"additional","affiliation":[{"name":"Department of Hematology Polo Universitario Pontino, S.M. Goretti Hospital Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-6162","authenticated-orcid":false,"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Policlinico Umberto I\u2010Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.04.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25214"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2019.05.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0313"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0233-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(20)30450-X"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30210-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-868752"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30010-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.303"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-733196"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2019.05.021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.03.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895\u20104356(95)00048\u20108"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2016.03.011"},{"issue":"1","key":"e_1_2_11_19_1","first-page":"129","article-title":"Practice Patterns and Outcomes for Adults With Acute Myeloid Leukemia Receiving Care in Community vs Academic Settings","volume":"2020","author":"Halpern A. 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