{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:30:50Z","timestamp":1788049850065,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2508905"],"award-info":[{"award-number":["2023YFC2508905"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103300"],"award-info":[{"award-number":["2022YFA1103300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470214"],"award-info":[{"award-number":["82470214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270227"],"award-info":[{"award-number":["82270227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z211100002921071"],"award-info":[{"award-number":["Z211100002921071"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Comparisons of safety and efficacy of Allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) following complete remission (CR) achieved by Chimeric antigen receptor T (CAR\u2010T) cell therapy versus chemotherapy for B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) have not been fully discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a comparison of transplant outcomes in 443 consecutive B\u2010ALL patients who received allo\u2010HSCT after achieving CR with CAR\u2010T therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950) or with chemotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009393). The median follow\u2010up time was 30\u2009months (range: 1\u201362\u2009months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The CAR\u2010T group had a lower incidence of chronic graft\u2010versus\u2010host disease (30.9% vs. 44.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). We also found that the incidence of veno\u2010occlusive disease was higher in the CAR\u2010T group compared to the chemotherapy group (4% vs. 0.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). The study revealed that both the CAR\u2010T and chemotherapy groups exhibited comparable overall survival (90.9% vs. 94.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.158) and relapse incidences (9.1% vs. 8.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.513). However, incidences of non\u2010relapse mortality after transplantation were higher in the CAR\u2010T group (10.9% vs. 4.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), and leukemia\u2010free survival was lower in the CAR\u2010T group compared to the chemotherapy group (80.0% vs. 86.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data indicate that, in B\u2010ALL patients, most treatment\u2010related complications and survival were comparable between CAR T\u2010cell therapy and chemotherapy followed by allo\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70108","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:44:07Z","timestamp":1768977847000},"page":"615-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bridging With Chimeric Antigen Receptor T\u2010Cell Therapy or Chemotherapy to Allo\u2010\n                    <scp>HSCT<\/scp>\n                    in B\u2010\n                    <scp>ALL<\/scp>\n                    : A Comparison of Treatment Complications and Survival"],"prefix":"10.1111","volume":"116","author":[{"given":"Ning","family":"Wu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kong","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lv","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Dong","family":"Mo","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Fei","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University Peking University People's Hospital, Peking University Institute of Hematology  Beijing 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