{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:18:46Z","timestamp":1780046326937,"version":"3.53.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013226","name":"Les Laboratories Pierre Fabre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epstein\u2013Barr virus\u2010positive post\u2010transplant lymphoproliferative disorder (EBV\u2009+\u2009PTLD) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo\u2010SCT). Given evolving transplantation practices, updated data are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Multicenter analysis of PTLD epidemiology, clinical characteristics, and outcomes in Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study across 17 Spanish transplant centers including all proven\/probable EBV+ PTLD cases after allo\u2010SCT from January 2000 to June 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 14.568 allo\u2010SCTs, 170 PTLD cases were identified (1.2%) peaking in 2010\u20132017 (2.0%), versus 0.9% in 2000\u20132009 and 0.7% in 2018\u20132023. Median onset was 91\u2009days; 75% occurred within 6\u2009months. Proven cases comprised 67%, mostly diffuse large B\u2010cell lymphoma. Advanced stage occurred in 67%, extranodal disease in 22%. Rituximab\u2009\u00b1\u2009immunosuppression reduction (ISR) was given to 80%, yielding a 62.4% response rate. Responders had superior survival (2\u2010year OS 73.4% vs. 10.7%). EBV\u2010specific cellular therapies were infrequently used. Median follow\u2010up was 97.8\u2009months; 5\u2010year OS 39.6%, with PTLD causing 49% of deaths. Severe hypoalbuminemia, lack of ISR, and rituximab refractoriness predicted worse survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EBV\u2009+\u2009PTLD frequency has declined in Spain. Prognosis remains poor for rituximab non\u2010responders, highlighting limited access to EBV\u2010specific cellular therapies as an unmet need.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70109","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:56:53Z","timestamp":1767851813000},"page":"450-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolving Patterns of\n                    <scp>EBV<\/scp>\n                    \u2010Associated\n                    <scp>PTLD<\/scp>\n                    After Allogeneic Stem Cell Transplantation: Frequency, Characteristics and Outcomes in a Multicenter\n                    <scp>GETH<\/scp>\n                    \u2010\n                    <scp>TC<\/scp>\n                    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