{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:40:12Z","timestamp":1791830412962,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008084","name":"Neurof\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polycythemia vera (PV) and essential thrombocythemia (ET) are associated with a well\u2010recognized increased risk of thrombotic events, bleeding, and all\u2010cause mortality, but the frequency of these outcomes during treatment has rarely been assessed in large cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this nationwide, population\u2010based study, we analyzed 2604 PV and 3141 ET patients using multiple Swedish health care registers, covering 43\u2009612 patient\u2010years. Rates of arterial and venous events, major bleeding, and all\u2010cause mortality (ACM) were evaluated across therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Unexpectedly, 42.3% of low\u2010risk PV patients and 29.7% of very low\/low\u2010risk ET patients received hydroxyurea (HU) during follow\u2010up. High\u2010risk PV patients treated with interferon (IFN) exhibited the lowest arterial event rate (2.21 per 100 patient\u2010years). In high\u2010risk ET, patients with IFN therapy experienced the lowest arterial and venous event rates (1.55 and 0.44 per 100 patient\u2010years). Advanced age and leukocytosis at diagnosis independently predicted thrombosis, bleeding, and ACM in both PV and ET. Multivariable analysis showed that HU and IFN were associated with reduced ACM risk; HU also conferred protection against thromboembolism and major bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights risk factors associated with complications during treatment in a real\u2010world context and reinforces the role of HU and IFN as first\u2010line therapies in PV and ET.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70113","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:47:46Z","timestamp":1768384066000},"page":"545-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Polycythemia Vera and Essential Thrombocythemia: A Nationwide Population\u2010Based Study on Treatment Patterns, Vascular Complications and Survival"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-3520","authenticated-orcid":false,"given":"Anneli Enblom","family":"Larsson","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Renlund","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Andr\u00e9asson","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine NU Hospital Group  Uddevalla Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Global Health Ume\u00e5 University  Ume\u00e5 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