{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:43:26Z","timestamp":1791924206018,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe renal insufficiency requiring dialysis in newly diagnosed multiple myeloma (NDMM) patients has been independently associated with poor survival outcomes. However, there is a paucity of data on factors predicting renal recovery and survival outcomes of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed outcomes in NDMM patients presenting with severe dialysis\u2010requiring RI from 01\/2010 to 12\/2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy patients were identified; all receiving novel agent\u2010based induction (bortezomib\u2010based 96%; lenalidomide\u2010based 3%)\u201473% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951) underwent ASCT. Thirty\u2010three (48%) patients became dialysis independent; early achievement of VGPR in &lt;\u20094.4\u2009months from treatment initiation was identified as the only factor predicting renal recovery and dialysis withdrawal on univariate analysis (Hazard ratio [HR] of 4.172;\n                      <jats:italic>p\u2010<\/jats:italic>\n                      value\u2009=\u20090.0014). At median follow\u2010up of 39\u2009months, the median overall survival (OS) of dialysis\u2010requiring NDMM patients was 98.3\u2009months with 2\u2010 and 5\u2010year OS rates of 84% and 67%, respectively; 2\u2010 and 5\u2010year progression\u2010free survival (PFS) rates were 66.9% and 43.7%, respectively. On multivariable analysis, low LDH at diagnosis (HR: 1.003,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0092), undergoing ASCT (HR: 0.213;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.0016), and dialysis independence (HR: 0.311;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.0112) independently predicted improved OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early VGPR and hemodialysis independence translated to improved survival, providing a benchmark for future comparison as anti\u2010CD38 monoclonal antibodies enter first line therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70116","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:51:11Z","timestamp":1768456271000},"page":"577-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Survival and Renal Recovery in Newly Diagnosed Multiple Myeloma Patients Presenting With Dialysis\u2010Requiring Severe Renal Impairment"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-1355","authenticated-orcid":false,"given":"Rintu","family":"Sharma","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshetu G.","family":"Atenafu","sequence":"additional","affiliation":[{"name":"Biostatistics, University Health Network  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Masih\u2010Khan","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjot","family":"Vohra","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita","family":"Bhella","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-3669","authenticated-orcid":false,"given":"Christine","family":"Chen","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Kukreti","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Lancman","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Prica","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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