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However, outcomes for patients with high\u2010risk AML remain dismal, and curative intent therapy is often challenging to administer in this population. AML is a highly plastic entity that employs a variety of mechanisms to circumvent immunosurveillance. In the recent decade, preclinical evidence for chimeric antigen receptor\u2010T (CAR\u2010T) and chimeric antigen receptor\u2010natural killer (CAR\u2010NK) therapies has gained traction in a variety of other hematologic malignancies, but the translation of these therapies to patients with AML has been limited. In this review, we discuss contemporary challenges to the clinical translation of cell\u2010based therapeutics in AML. We underscore practical solutions to facilitating the clinical availability of novel cell\u2010based therapies in AML. 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