{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:19:24Z","timestamp":1785453564531,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["18134"],"award-info":[{"award-number":["18134"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non\u2010infectious fever. T2 magnetic resonance (T2MR) is a culture\u2010independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay providing a likelihood of sepsis (SeptiScore).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted an observational study including bone marrow transplant patients with febrile neutropenia to assess (1) the performance of T2MR versus\n                      <jats:sc>BC<\/jats:sc>\n                      (2) the performance of SeptiScore in providing valid results and diagnosing infection compared to a retrospective clinician diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 90 febrile episodes. Eleven episodes had BC growing bacteria, of which 3\/11 were T2Bacteria on\u2010panel pathogens. T2Candida identified four\n                      <jats:italic>Candida<\/jats:italic>\n                      with a turnaround time of 3.0\u2009h (IQR 3.0\u20133.0), significantly shorter than BC (42.4\u2009h, IQR 39.8\u201350.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). A SeptiScore was obtained in 86\/90 cases. Febrile episodes were classified as: infectious (21\/86, 24%), probably infectious (13\/86, 15%), indeterminate (excluded from analysis; 40\/86, 46%), non\u2010infectious (12\/86, 14%). The AUC of SeptiScore for infectious fever was 0.84 (95% CI 0.71\u20130.97).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the short turnaround time, T2MR showed limited coverage of bloodstream pathogens. SeptiScore may help in diagnosing infectious neutropenic fever, but larger studies should clarify its clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70122","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T03:00:48Z","timestamp":1769223648000},"page":"625-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Host Transcriptomics and Culture\u2010Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-4728","authenticated-orcid":false,"given":"Anna Maria","family":"Peri","sequence":"first","affiliation":[{"name":"UQ Centre for Clinical Research The University of Queensland  Brisbane Queensland Australia"},{"name":"Herston Infectious Diseases Institute, Herston  Brisbane Queensland Australia"},{"name":"Infectious Diseases Unit Royal Brisbane and Women's Hospital  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S.","family":"Henden","sequence":"additional","affiliation":[{"name":"Department of Cancer Care Services Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"},{"name":"QIMR Berghofer Medical Research Institute  Herston Queensland Australia"},{"name":"Faculty of Health, Medicine and Behavioural Sciences University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0246-5691","authenticated-orcid":false,"given":"Ricky","family":"Nelles","sequence":"additional","affiliation":[{"name":"Department of Cancer Care Services Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Chatfield","sequence":"additional","affiliation":[{"name":"UQ Centre for Clinical Research The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick N. 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