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To address this demand, we performed a random\u2010effects meta\u2010analysis evaluating response rates to salvage treatments after anti\u2010BCMA CAR\u2010T failure. We identified 36 eligible studies comprising 476 patients and seven distinct interventions through systematic database screening. Among them, bispecific antibodies (bsAbs) were the most common choice, followed by anti\u2010BCMA CAR\u2010T cells. We separately assessed response rates to both first\u2010 and any subsequent (combined)\u2010line salvage interventions. In the first\u2010line setting, selinexor\u2010based regimens yielded the highest overall response rates (ORR) of 67% (95% CI: 38%\u201391%), followed by bsAbs (60%; 95% CI: 43%\u201376%). In the combined setting, anti\u2010GPRC5D CAR\u2010T cells achieved the highest ORR (88%; 95% CI: 65%\u2013100%), followed by anti\u2010BCMA CAR\u2010T cells (75%; 95% CI: 42%\u201398%). Belantamab mafodotin demonstrated the lowest efficacy (0%; 95% CI: 0%\u201317%). Complete response rates remained low across all interventions (range: 0%\u201340%). Heterogeneity investigations revealed superior responses with human\/humanized anti\u2010BCMA CAR\u2010T constructs compared with the animal\u2010based receptors. In summary, our meta\u2010analysis suggested that CAR\u2010T cells and bsAbs are suitable for salvage use after anti\u2010BCMA CAR\u2010T failure in MM.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO number: CRD42024621077\n                  <\/jats:p>","DOI":"10.1111\/ejh.70123","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:21:59Z","timestamp":1769505719000},"page":"663-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Salvage Therapies After Anti\u2010BCMA CAR\u2010T Failure in Patients With Multiple Myeloma: A Meta\u2010Analysis of Response Rates"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0255-3138","authenticated-orcid":false,"given":"Jaromir","family":"Tomasik","sequence":"first","affiliation":[{"name":"Department of Hematology, Transplantation and Internal Medicine Medical University of Warsaw  Warsaw Poland"},{"name":"Doctoral School Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Shouval","sequence":"additional","affiliation":[{"name":"Department of Medicine, Adult Bone Marrow Transplantation Service Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Medicine Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Gafter\u2010Gvili","sequence":"additional","affiliation":[{"name":"Department of Medicine A and Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center Beilinson Hospital  Petah\u2010Tikva Israel"},{"name":"Faculty of Medical and Health Sciences Tel Aviv University  Tel\u2010Aviv 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