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Pomalidomide, cyclophosphamide and dexamethasone (PCd) remain a valid treatment option in this setting. This retrospective, multicentric study evaluated the activity and safety of PCd in patients with RRMM treated following standard clinical practice. A total of 179 patients were included. The median age was 72\u2009years; most were triple\u2010refractory (59.8%), being 162 patients (90.5%) refractory to lenalidomide and 117 (65.4%) to anti\u2010CD38. The overall response rate (ORR) was 59.8% (95% CI: 52.2\u201367.0). Triple\u2010refractory patients had an ORR of 52.3% (95% CI: 42.5\u201362.1). The median progression\u2010free survival (PFS) and overall survival (OS) were 7.9\u2009months (95% CI: 6.8\u201310.1) and 16.1\u2009months (95% CI: 12.8\u201320.5), respectively. Patients refractory to lenalidomide and anti\u2010CD38 had a median PFS of 7.6 months (95% CI: 5.8\u20139.4) and 7.6 months (95% CI: 5.8\u20139.4), respectively. Most frequent grade 3\u20134 adverse events were neutropenia (57.5%), anaemia (30.7%) and thrombocytopenia (29.6%). PCd demonstrated effectiveness in double\u2010 and triple\u2010refractory RRMM patients, including those refractory to anti\u2010CD38 and is a viable treatment option for these patients.<\/jats:p>","DOI":"10.1111\/ejh.70126","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:25:31Z","timestamp":1770445531000},"page":"806-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pomalidomide, Cyclophosphamide and Dexamethasone (\n                    <scp>PCd<\/scp>\n                    ): Outcomes in Patients With Double\u2010 or Triple\u2010Refractory Multiple Myeloma"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-6752","authenticated-orcid":false,"given":"Marta","family":"Hidalgo\u2010Soto","sequence":"first","affiliation":[{"name":"Haematology Department Instituto de Investigaciones Biom\u00e9dicas August pi i Sunyer (IDIBAPS)  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