{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:24:02Z","timestamp":1777983842966,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01CA023766"],"award-info":[{"award-number":["P01CA023766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08CA282987"],"award-info":[{"award-number":["K08CA282987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["696\/23"],"award-info":[{"award-number":["696\/23"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","award":["2024009"],"award-info":[{"award-number":["2024009"]}],"id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016947","name":"Swim Across America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    CAR\u2010T cell therapy is efficient in relapsed\/refractory B\u2010cell lymphoma; yet, cytokine release syndrome (CRS) and immune effector cell\u2010associated neurotoxicity syndrome (ICANS) remain major and potentially life\u2010threatening complications, which makes their prediction and prevention crucial. This international, retrospective study analyzed the predictive value of coagulation parameter dynamics for ICANS and CRS development in 265 B\u2010cell lymphoma patients at two tertiary\u2010care centers. Platelet counts, fibrinogen, PT, PTT, international normalized ratio, and D\u2010dimer, were recorded daily from pre\u2010lymphodepletion through 2\u2009weeks post\u2010infusion. ICANS occurred in 34% of patients, with high\u2010grade events documented in 13%. Patients with ICANS had significantly lower median platelet (67 vs. 123\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    \/\u03bcL) and fibrinogen (263 vs. 379\u2009mg\/dL) levels than those without ICANS. During high\u2010grade ICANS days, fibrinogen and platelet levels were significantly reduced (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.6\u2009\u00d7\u200910\n                    <jats:sup>\u221214<\/jats:sup>\n                    , respectively). In &gt;\u200975% of high\u2010grade ICANS cases, 1\u2009day before its onset, platelet counts were &lt;\u2009100\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L (median decrease: 11.6% versus 1.6% on other days;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Conversely, on the day preceding ICANS onset, higher fibrinogen concentrations were observed, with median values of 448\u2009mg\/dL in the ICANS group versus 376\u2009mg\/dL in the non\u2010ICANS group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). These findings suggest that platelet and fibrinogen dynamics could be early indicators of ICANS development in lymphoma patients.\n                  <\/jats:p>","DOI":"10.1111\/ejh.70139","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:59:53Z","timestamp":1770958793000},"page":"835-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet and Fibrinogen Dynamics After\n                    <scp>CAR<\/scp>\n                    \u2010T Cell Therapy in Relapsed\/Refractory B\u2010Cell Lymphoma May Predict\n                    <scp>ICANS<\/scp>\n                    Onset"],"prefix":"10.1111","volume":"116","author":[{"given":"Hazim","family":"Khatib","sequence":"first","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Parizat","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jabour","family":"Halloun","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roni","family":"Shouval","sequence":"additional","affiliation":[{"name":"Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center  New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niveen","family":"Shibli","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onit","family":"Alalouf","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-977X","authenticated-orcid":false,"given":"Tsila","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Halamish","sequence":"additional","affiliation":[{"name":"Computer Department Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Sapir","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Yehudai\u2010Ofir","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-1466","authenticated-orcid":false,"given":"Shimrit","family":"Ringelstein\u2010Harlev","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7076-6501","authenticated-orcid":false,"given":"Netanel A.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-8940","authenticated-orcid":false,"given":"Noa","family":"Lavi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurit","family":"Horesh","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riva","family":"Fineman","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-1307","authenticated-orcid":false,"given":"Inna","family":"Tzoran","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9327-5999","authenticated-orcid":false,"given":"Tsofia","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-7805","authenticated-orcid":false,"given":"Eldad J.","family":"Dann","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Mruwat","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayal","family":"Rozenberg","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Technion  Haifa Israel"},{"name":"Department of Neurology Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Shechtman","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Technion  Haifa Israel"},{"name":"Faculty of Electrical and Computer Engineering, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0088-5990","authenticated-orcid":false,"given":"Ofrat","family":"Beyar\u2010Katz","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00754-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00933-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024850"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31366-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804980"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01222-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707447"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.950923"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-09102-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1852474"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004716"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2030475"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.11.027"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19583"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002288"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005898"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002060"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098349"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3155"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03685-z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18596"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01226-9"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-793141"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0698"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-3814"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002757"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-023-02169-z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003885"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147652"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007454"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008066"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025028833"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.70139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:04:33Z","timestamp":1777982673000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ejh.70139"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70139","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"2025-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}