{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:25:34Z","timestamp":1782123934473,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extended\u2010duration anticoagulation reduces recurrent venous thromboembolism (VTE) in cancer and non\u2010cancer patients. Reduced\u2010dose direct oral anticoagulants (DOACs) may be safer if they match efficacy with less bleeding risk. We conducted a systematic review and meta\u2010analysis of trials comparing reduced\u2010dose and extended\u2010dose DOACs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized controlled trials comparing reduced\u2010dose with extended\u2010dose anticoagulation for secondary VTE prevention were systematically reviewed. Primary outcomes included recurrent symptomatic VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT). Secondary outcomes included bleeding, adverse events, and all\u2010cause mortality. Risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using random\u2010effects models. Subgroup and leave\u2010one\u2010out sensitivity analyses explored heterogeneity and robustness. All analyses were conducted in R (version 4.3.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099382) were included. Reduced\u2010dose anticoagulation showed no statistically significant difference in recurrent VTE (RR 0.98, 95% CI 0.72\u20131.33), PE (RR 0.96, 95% CI 0.61\u20131.50), or DVT (RR 0.86, 95% CI 0.56\u20131.32) compared with extended\u2010dose therapy. Major bleeding was significantly reduced (RR 0.68, 95% CI 0.48\u20130.98), as were clinically relevant non\u2010major bleeding and any bleeding. All\u2010cause mortality did not differ significantly. Heterogeneity was low to moderate across outcomes, and sensitivity analyses confirmed the stability of results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduced\u2010dose anticoagulation demonstrated similar efficacy with improved safety compared with extended\u2010dose therapy. These findings support individualized dose reduction strategies after extended anticoagulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: CRD420251081952<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70142","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:00:21Z","timestamp":1771826421000},"page":"863-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reduced\u2010 Versus Extended\u2010Dose Anticoagulation for Venous Thromboembolism in Patients With and Without Cancer: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9161-3074","authenticated-orcid":false,"given":"Muhammad Faizan","family":"Ali","sequence":"first","affiliation":[{"name":"Jinnah Postgraduate Medical Center  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Naseer","sequence":"additional","affiliation":[{"name":"Nishtar Medical University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0933-0426","authenticated-orcid":false,"given":"Ahmed W.","family":"Hageen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shariq","family":"Hayat","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-5726","authenticated-orcid":false,"given":"Zarwa","family":"Rashid","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. N. U.","family":"Momna","sequence":"additional","affiliation":[{"name":"Peoples University of Medical and Health Sciences for Women  Nawabshah Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. N. U.","family":"Sawaira","sequence":"additional","affiliation":[{"name":"Khyber Girls Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3670-228X","authenticated-orcid":false,"given":"Abdul Ahad","family":"Riaz","sequence":"additional","affiliation":[{"name":"Nishtar Medical University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husnain","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Shalamar Medical and Dental College  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Eltawansy","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Jersey Shore University Medical Center  Neptune City New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hossain","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Jersey Shore 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