{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:27:31Z","timestamp":1777984051906,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["501830041"],"award-info":[{"award-number":["501830041"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014276","name":"Doktor Robert Pfleger-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","award":["2018.072.1"],"award-info":[{"award-number":["2018.072.1"]}],"id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","award":["2021.007.1"],"award-info":[{"award-number":["2021.007.1"]}],"id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Allogeneic stem cell transplantation (allo\u2010SCT) and donor lymphocyte infusions (DLI) can elicit a graft\u2010versus\u2010leukemia (GvL) effect in pediatric patients with hematological malignancies. We report our single\u2010center experience with prophylactic DLI in high\u2010risk pediatric patients with leukemia or lymphoma, focusing on feasibility, safety, and efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In total, 10 high\u2010risk patients received prophylactic DLI following allo\u2010SCT. Donors were either matched (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) or haploidentical (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095). CD3+ T\u2010cell doses of up to 1\u2009\u00d7\u200910\n                      <jats:sup>7<\/jats:sup>\n                      cells\/kg body weight were administered, in some cases over extended periods exceeding three years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The treatment was associated with a favorable toxicity profile. In our cohort, 40% of patients developed moderate acute (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) or chronic (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) graft\u2010versus\u2010host disease (GvHD); no cases of severe or high grade GvHD occurred. Given the high\u2010risk profile of our cohort, outcomes were encouraging, with relapse\u2010free survival (RFS) of 70% and overall survival (OS) of 80% at a median follow\u2010up of 20.5\u2009months. Especially, the two subgroups of patients with acute myeloid leukemia (AML) after relapse and patients who were transplanted in first complete remission (CR1) showed outcomes superior to currently reported data. One AML patient, who had experienced three relapses, received prophylactic DLI after a third allo\u2010SCT and remains in complete remission (CR), more than 3\u2009years after the last allo\u2010SCT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data suggest that prophylactic DLI may represent a safe and effective treatment option for pediatric patients with hematological malignancies at high risk of posttransplant relapse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70149","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:31:10Z","timestamp":1773001870000},"page":"907-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prophylactic Donor Lymphocyte Infusions in Pediatric Patients With High\u2010Risk Hematological Malignancies"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4808-5223","authenticated-orcid":false,"given":"Denise","family":"Epple","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's Cancer Research Center, Kinderklinik M\u00fcnchen Schwabing, TUM School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Gall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Cancer Research Center, Kinderklinik M\u00fcnchen Schwabing, TUM School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Paschke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Cancer Research Center, Kinderklinik M\u00fcnchen Schwabing, TUM School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-7987","authenticated-orcid":false,"given":"Hans\u2010Jochem","family":"Kolb","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Immunology Infectious Diseases Klinikum M\u00fcnchen Schwabing  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Wawer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Cancer Research Center, Kinderklinik M\u00fcnchen Schwabing, TUM School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Knabe","sequence":"additional","affiliation":[{"name":"Bavarian Stem Cell Bank (Bayerische Stammzellbank)  Gauting Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"von Luettichau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Cancer Research Center, Kinderklinik M\u00fcnchen Schwabing, TUM School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Hauer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Cancer Research Center, Kinderklinik M\u00fcnchen Schwabing, TUM School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Thiel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Cancer Research Center, Kinderklinik M\u00fcnchen Schwabing, TUM School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30186\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(22)00637\u20104"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061405"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609783"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/children7020014"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2017.1270202"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.3.555.bloodjournal753555"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201003\u2010077974"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.03.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.5.2041.bloodjournal8652041"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(24)00098\u2010X"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010021\u201001515\u20103"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.03.004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.326"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.6053"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.10.009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.227"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203517"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102336"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040789"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102019\u2010131131"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010023\u201002137\u20107"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.70149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:05:13Z","timestamp":1777982713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ejh.70149"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70149","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]},"assertion":[{"value":"2025-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}