{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:50:48Z","timestamp":1781877048002,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for paroxysmal nocturnal hemoglobinuria (PNH). Post\u2010transplant cyclophosphamide (PTCy) has improved HSCT safety in other diseases, but its use in PNH is poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we analyzed outcomes of 19 patients with large PNH clones (\u2265\u200950%) undergoing HSCT (2016\u20132025). Seven patients received a PTCy\u2010based platform (fludarabine\u2010busulfan\u2010cyclophosphamide conditioning with PTCy\u2010based graft\u2010versus\u2010host disease [GvHD] prophylaxis), whereas 12 received conventional prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients' median age was 32\u2009years; 68% had PNH with bone marrow failure. After a median follow\u2010up of 1349\u2009days, overall and event\u2010free survival rates were 100% and 94.4%, respectively. All patients engrafted rapidly with full donor chimerism. No cases of chronic or grades II\u2013IV acute GvHD occurred in the PTCy group (0\/7); however, chronic GvHD and grades II\u2013IV acute GvHD occurred in 15.8% and 10.5% of patients in the conventional group, respectively. No transplant\u2010related mortality or thrombotic events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study, representing the largest reported experience with PTCy\u2010based HSCT for PNH, suggests that this platform is feasible and associated with excellent survival and a promising GvHD profile. These preliminary findings support further investigation of PTCy in transplant strategies for PNH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70162","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:34:18Z","timestamp":1773365658000},"page":"154-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allogeneic Hematopoietic Cell Transplantation Using Post\u2010Transplant Cyclophosphamide in Patients With Large Paroxysmal Nocturnal Hemoglobinuria Clones"],"prefix":"10.1111","volume":"117","author":[{"given":"Qiangsheng","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Hematology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-9323","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1572-1640","authenticated-orcid":false,"given":"Can","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Hunan Provincial People's Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology First People's Hospital of Chenzhou  Chenzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of 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