{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:12:46Z","timestamp":1791403966640,"version":"4.3.3"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platelet transfusion is commonly used to reduce bleeding risk in platelet consumptive disorders. However, platelets may also promote thromboinflammatory pathways, and contemporary data evaluating the association between platelet transfusion, thrombosis, and mortality in this population are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study using the National Inpatient Sample from 2018 to 2021. Non\u2010elective hospitalizations with immune thrombocytopenic purpura, thrombotic thrombocytopenic purpura, heparin\u2010induced thrombocytopenia, or other primary thrombocytopenias were included. The exposure was receipt of any platelet transfusion during hospitalization. Primary outcomes were in\u2010hospital mortality and in\u2010hospital thrombotic events, defined as venous thromboembolism or arterial thrombosis using ICD\u201010\u2010CM codes. Inverse probability of treatment weighting and survey\u2010weighted logistic regression were used to adjust for demographics, comorbidities, illness severity, major bleeding, and disease\u2010specific therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 67\u2009405 hospitalizations (337\u2009705 weighted national estimates), 10.5% received platelet transfusion. Mortality was higher in transfused versus nontransfused hospitalizations (9.5% vs. 6.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After adjustment, platelet transfusion was associated with increased odds of in\u2010hospital mortality (adjusted odds ratio [aOR], 1.42; 95% CI: 1.28\u20131.60) and thrombosis (any thrombosis: aOR, 1.28; 95% CI: 1.18\u20131.39). Associations were observed for venous (aOR, 1.39) and arterial thrombosis (aOR, 1.15). Thrombotic risk persisted among hospitalizations without major bleeding but was attenuated with major bleeding. Intravenous immunoglobulin was associated with higher odds of thrombosis, while plasma exchange was associated with lower odds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients hospitalized with platelet consumptive disorders, platelet transfusion was associated with higher odds of in\u2010hospital thrombosis and mortality, supporting judicious, indication\u2010driven transfusion practices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70165","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:11:02Z","timestamp":1775643062000},"page":"245-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Platelet Transfusion Is Associated With Increased Thrombosis and In\u2010Hospital Mortality Among Patients Hospitalized With Platelet Consumptive Disorders"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-0389","authenticated-orcid":false,"given":"Manas","family":"Pustake","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Science Center El Paso  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhangi","family":"Deoker","sequence":"additional","affiliation":[{"name":"BJ Medical College and Sasson General Hospitals  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-808X","authenticated-orcid":false,"given":"Veeravenkata","family":"Garikiparthy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Science Center El Paso  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-0706","authenticated-orcid":false,"given":"Kunal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Science Center El Paso  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Kattamuri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Science Center El Paso  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhizith","family":"Deoker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Science Center El Paso  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Deol","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute, Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2023000465"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1410951"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S464365"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2021.07.005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.10.012"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18277"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000136"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/17511437231206013"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.7529"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201010\u2010605493"},{"key":"e_1_2_12_12_1","unstructured":"Healthcare 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