{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:57:06Z","timestamp":1790996226889,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>New therapies are improving outcomes even in advanced stages of multiple myeloma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the experience of bispecific antibodies (BsAbs) in Mexico.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 41 patients with triple\u2010class refractory (88%) and penta\u2010drug refractory (61%) myeloma. The median number of prior treatment lines was 3, and the median time to response was 2\u2009months. Step\u2010up dosages were administered on an outpatient basis in 34 patients (83%). BsAbs were administered every 2\u2009weeks to 19 patients (46%) and monthly to 17 patients (41.5%). Thirteen of these (31.5%) switched to monthly doses early in treatment and maintained their response. Twenty\u2010five of 38 evaluated patients (66%) achieved a complete response or better, and 84% were negative for minimal residual disease. The median response duration was 10\u2009months, while median progression\u2010free survival and overall survival were 12 and 13\u2009months, respectively. Extramedullary disease, no complete response, positivity for minimal residual disease, and penta\u2010refractoriness were associated with poor outcomes. The adverse events were lower than those reported in clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, using outpatient step\u2010up dosing followed by planned de\u2010escalation to monthly doses of BsAbs in responding patients with MM is feasible, safe, and effective, and may improve access to this novel therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70176","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:34:16Z","timestamp":1774485256000},"page":"200-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outpatient Delivery of Step\u2010Up Doses to Rapidly Initiate Monthly Doses of Bispecific Antibodies in Multiple Myeloma"],"prefix":"10.1111","volume":"117","author":[{"given":"Aline 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