{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:50:47Z","timestamp":1781877047286,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myelodysplastic neoplasia (MDS) comprises heterogeneous clonal hematologic disorders characterized by peripheral cytopenia, bone marrow dysplasia, and a risk of leukemic transformation. A hypoplastic variant (MDS\u2010h) shares features with aplastic anemia and responds to immunosuppressive therapy (IST). We report three low\u2010risk MDS\u2010h cases treated with IST and monitored over 9\u201317\u2009years using serial cytogenetic and molecular analyses. All patients achieved transfusion independence after IST, and two experienced durable, long\u2010term remissions. One patient developed late clonal evolution culminating in secondary acute myeloid leukemia. Molecular follow\u2010up revealed diverse mutational dynamics, including stable and fluctuating clones and delayed mutational emergence, detectable in peripheral blood. These findings suggest that in MDS\u2010h, disease activity is largely driven by immune dysregulation rather than early molecular changes, and that repeated IST can yield sustained remissions. However, accumulating mutations may eventually predict malignant transformation, underscoring the importance of long\u2010term molecular monitoring.<\/jats:p>","DOI":"10.1111\/ejh.70179","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:19:05Z","timestamp":1774869545000},"page":"274-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Clinical and Molecular Dynamics in Hypoplastic Myelodysplastic Neoplasia Treated With Immunosuppressive Therapy"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-5493","authenticated-orcid":false,"given":"Hannes","family":"Treiber","sequence":"first","affiliation":[{"name":"Clinics of Hematology and Medical Oncology University Medicine G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"INDIGHO Laboratory University Medicine G\u00f6ttingen  G\u00f6ttingen 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