{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:18:12Z","timestamp":1783012692912,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adult T\u2010cell leukemia\/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor\u2010specific therapeutic target. We previously isolated an ATL\u2010specific single\u2010chain variable fragment (scFv), S1TSCFR3\u20101, that selectively binds to ATL cell surface glycans. In this study, we engineered natural killer (NK) cells to express a chimeric antigen receptor (CAR) incorporating S1TSCFR3\u20101 and evaluated their therapeutic potential against ATL. In\u00a0vitro, CAR\u2010NK cells exhibited dose\u2010dependent cytotoxicity against ATL cell lines, mediated primarily through enhanced granzyme B production, whereas no augmentation of cytotoxic activity was observed against non\u2010ATL cell lines. S1TSCFR3\u20101 binding was detected in PBMCs from 3 of 7 ATL patients, and CAR\u2010NK cells demonstrated significant cytotoxicity against PBMCs from a binding\u2010positive patient. In a xenograft mouse model, administration of irradiated CAR\u2010NK cells partially suppressed tumor burden as evidenced by reduced serum hsIL\u20102R levels, although survival benefit did not reach statistical significance. These findings suggest that CAR\u2010NK cell therapy targeting ATL\u2010associated aberrant glycan epitopes represents a potentially valuable therapeutic approach warranting further investigation.<\/jats:p>","DOI":"10.1111\/ejh.70199","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:10:44Z","timestamp":1777849844000},"page":"481-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of Chimeric Antigen Receptor\u2010Modified\n                    <scp>NK<\/scp>\n                    \u00a0Cells for the Immunotherapy of Adult T\u2010Cell Leukemia\/Lymphoma"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8378-8923","authenticated-orcid":false,"given":"Yuichiro","family":"Uchida","sequence":"first","affiliation":[{"name":"SUDx\u2010Biotec Corporation  Kagoshima 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