{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:18:37Z","timestamp":1783012717470,"version":"3.54.6"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy has become an established treatment for hematological malignancies. Lymphodepleting (LD) chemotherapy is a preparatory step that facilitates CAR\u2010T cell expansion and persistence. While fludarabine and cyclophosphamide (Flu\/Cy) are a standard LD regimen, bendamustine has emerged as a potential alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and meta\u2010analysis comparing the efficacy and safety of bendamustine versus Flu\/Cy as LD regimens. We systematically searched PubMed, Scopus, and the Cochrane Central Register of Controlled Trials from inception to July 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine retrospective studies comprising 768 patients were included. The bendamustine cohort demonstrated a lower incidence of all\u2010grade cytokine release syndrome (CRS) compared with Flu\/Cy (60.2% vs. 71.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), whereas no difference was observed in grade \u2265\u20093 CRS. Overall infections were less frequent with bendamustine (18.3% vs. 53.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There were no significant differences between groups in the incidence of immune effector cell\u2010associated neurotoxicity syndrome, overall response rate, overall survival, and progression\u2010free survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bendamustine LD therapy significantly reduced the incidence of all\u2010grade CRS and overall infections without compromising CAR\u2010T efficacy. These findings suggest that bendamustine may serve as a viable alternative LD regimen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70205","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:16:06Z","timestamp":1777619766000},"page":"467-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Bendamustine Versus Fludarabine and Cyclophosphamide as Lymphodepleting Regimens for\n                    <scp>CAR<\/scp>\n                    \u2010T Therapy in Hematological Malignancies: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1452-039X","authenticated-orcid":false,"given":"Akihiro","family":"Miyashita","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Hawai\u02bbi John A. Burns School of Medicine  Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda Sof\u00eda Jim\u00e9nez","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Facultad de Medicina C\u2010II \u201cDr. Manuel Velasco Su\u00e1rez\u201d Universidad Aut\u00f3noma de Chiapas, Tuxtla Guti\u00e9rrez  Chiapas Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-8231","authenticated-orcid":false,"given":"Thomas","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Hawaii Pacific Health  Honolulu Hawaii USA"},{"name":"Department of Veterans Affairs  Raleigh North Carolina USA"},{"name":"Department of Medicine University of Hawai\u02bbi  Honolulu Hawaii 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