{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:13:16Z","timestamp":1788513196130,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Erdheim\u2010Chester Disease (\n ECD<\/jats:styled-content>\n ) and Rosai\u2010Dorfman Disease (\n RDD<\/jats:styled-content>\n ) Are Rare Non\u2010Langerhans Cell Histiocytoses That Share Several Clinical and Histological Features, Including the Accumulation of\n CD1a<\/jats:styled-content>\n \u2010 Histiocytes in Organs. Cladribine, a Purine Analog, Leads to an Overall Response Rate (\n ORR<\/jats:styled-content>\n ) of 91% in Langerhans\u2010Cell Histiocytoses. Whether the Same Results Could Be Obtained in Non\u2010Langerhans Cell Histiocytoses Remains To Be Determined.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n We retrospectively assessed the efficacy of cladribine according to clinical and radiological responses in consecutive patients with a diagnosis of ECD, RDD, or non\u2010classified non\u2010Langerhans cell histiocytosis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010One Patients Were Included in This Study (17 Males, Median Age at Cladribine Treatment 53\u2009Years). The Clinical\n ORR<\/jats:styled-content>\n Was 62% (44% in\n ECD<\/jats:styled-content>\n , 70% in\n RDD<\/jats:styled-content>\n ), whereas the Radiological\n ORR<\/jats:styled-content>\n Was 43% (44% in\n ECD<\/jats:styled-content>\n , 30% in\n RDD<\/jats:styled-content>\n ). Four of Five Patients With Cranial Nerve Palsy Responded Clinically (80%), whereas Pseudo\u2010Degenerative\n CNS<\/jats:styled-content>\n Involvement Did Not Improve (\n n<\/jats:italic>\n \u2009=\u20093). Six Patients With Multisystemic Involvement Did Not Require Additional Treatment After Achieving a Radiological Response (\n n<\/jats:italic>\n \u2009=\u20094) or After Achieving Radiological Stable Disease (\n n<\/jats:italic>\n \u2009=\u20092), with a Median Follow\u2010Up of 2.3\u2009Years (Range 0.5\u20139.5). After They Achieved a Radiological Response, 4\/9 (44%) Patients Relapsed in a Median Time of 18\u2009Months (Range 6\u201395). The Safety Profile Showed That 19\/19 Patients Experienced Lymphopenia, Whereas Only 2\/19 Had Clinical Infectious Events (9%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These Results Provide New Evidence of the Efficacy of Cladribine in Non\u2010Langerhans Cell Histiocytosis and Brings New Data on the Safety Profile of This Drug in Histiocytoses.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ejh.70208","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:56:43Z","timestamp":1777942603000},"page":"892-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Tolerance of Cladribine for Non\u2010Langerhans Cell Histiocytosis"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-0235","authenticated-orcid":false,"given":"Quentin","family":"Riller","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique\u2010H\u00f4pitaux De Paris, Service de M\u00e9decine Interne 2, Centre National De R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares et Histiocytoses, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, Centre D'immunologie et Des Maladies Infectieuses, INSERM\u2010CNRS U1135 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thouraya","family":"Ben Salem","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique\u2010H\u00f4pitaux De Paris, Service de M\u00e9decine Interne 2, Centre National De R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares et Histiocytoses, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, Centre D'immunologie et Des Maladies Infectieuses, INSERM\u2010CNRS U1135 Paris 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