{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:13:09Z","timestamp":1788513189396,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","award":["IST\u201020\u201011291"],"award-info":[{"award-number":["IST\u201020\u201011291"]}],"id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["COV20\/00399"],"award-info":[{"award-number":["COV20\/00399"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","award":["22905\/EE\/25"],"award-info":[{"award-number":["22905\/EE\/25"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Endothelial dysfunction is key in COVID\u201019 pathogenesis. This randomized, double\u2010blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS\u2010CoV\u20102 infection and respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One\u2010hundred and fifty patients were randomized (2:1) to defibrotide or placebo, stratified by disease severity (WHO COVID\u201019 severity scale 4\/5 vs. 6). The primary endpoint was clinical improvement time (days from first improvement through Day 30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median clinical improvement time was not significantly different with defibrotide versus placebo (15.0 [IQR: 0\u201324] vs. 20.0 [IQR: 9\u201325] days;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10). Day\u201030 (23.0% vs. 22.0%) and Day\u201060 (26.0% vs. 22.0%) mortality, reduction in mean fraction of inspired oxygen during treatment, and median duration of hospitalization did not differ with defibrotide versus placebo. Defibrotide demonstrated favorable safety, with no differences versus placebo in serious adverse events (34.0% vs. 36.0%), hypotension (16.0% vs. 12.0%), or hemorrhage (13.0% vs. 8.0%). Exploratory pre\u2010specified biomarker analyses showed greater early\n                      <jats:sc>d<\/jats:sc>\n                      \u2010dimer reduction and lymphocyte recovery with defibrotide, although these results require validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Continuous intravenous infusion of defibrotide was safe but did not improve clinical outcomes in severe COVID\u201019. Further analyses will explore mechanistic actions and pharmacokinetics of defibrotide and the pathophysiology of endothelial dysfunction in COVID\u201019.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      EudraCT identifier: 2020\u2010001409\u201021. Clinicaltrials.gov identifier: NCT04348383\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70214","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:29:50Z","timestamp":1778585390000},"page":"922-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phase\n                    <scp>IIB<\/scp>\n                    , Randomized, Double\u2010Blind, Placebo\u2010Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in\n                    <scp>COVID<\/scp>\n                    \u201019"],"prefix":"10.1111","volume":"117","author":[{"given":"Ruben","family":"Jara Rubio","sequence":"first","affiliation":[{"name":"Intensive Care Service, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Jos\u00e9","family":"Martinez\u2010Mellado","sequence":"additional","affiliation":[{"name":"Hematology Department, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kiwitt\u2010C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Preventive Medicine Department, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5800-319X","authenticated-orcid":false,"given":"Jos\u00e9 G.","family":"Clavel","sequence":"additional","affiliation":[{"name":"Department of Quantitative Methods, Faculty of Economics and Business University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartolom\u00e9","family":"Garc\u00eda\u2010Perez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Hospital Clinic, IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Diaz\u2010Ricart","sequence":"additional","affiliation":[{"name":"Hematopathology, Pathology Department, Centre of Biomedical Diagnosis (CDB), Hospital Clinic University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Carrillo\u2010Alcaraz","sequence":"additional","affiliation":[{"name":"Intensive Care Service, University Hospital Morales Meseguer, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"L\u00f3pez\u2010Bern\u00fas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Clinical Hospital  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Bernal Morell","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, University Hospital Reina Sofia, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aychel","family":"Roura","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5924-2196","authenticated-orcid":false,"given":"Sonia","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco\u2010Jos\u00e9","family":"Ruiz\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pulmonology Department, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Solana\u2010Martinez","sequence":"additional","affiliation":[{"name":"Pulmonology Department, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Martinez\u2010Ba\u00f1o","sequence":"additional","affiliation":[{"name":"Intensive Care Service, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos L.","family":"Albacete Moreno","sequence":"additional","affiliation":[{"name":"Intensive Care Service, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enriqueta","family":"Andreu Soler","sequence":"additional","affiliation":[{"name":"Intensive Care Service, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Tellez Santoyo","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Hospital Clinic, IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fern\u00e1ndez M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Hospital Clinic, IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Noguera Velasco","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Service, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"Cebreiros Lopez","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Service, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Parrilla","sequence":"additional","affiliation":[{"name":"Image Diagnostic Service University Hospital Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Espuny\u2010Mir\u00f3","sequence":"additional","affiliation":[{"name":"Pharmacy Department, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6610-8442","authenticated-orcid":false,"given":"David","family":"Garc\u00eda\u2010Bernal","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplant and Cellular Therapy Unit, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Blanquer","sequence":"additional","affiliation":[{"name":"Hematology Department, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"S\u00e1nchez\u2010Salinas","sequence":"additional","affiliation":[{"name":"Hematology Department, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Iniesta","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplant and Cellular Therapy Unit, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Hernandez Garcia","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplant and Cellular Therapy Unit, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Muro","sequence":"additional","affiliation":[{"name":"Immunology Department University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Minguela Puras","sequence":"additional","affiliation":[{"name":"Immunology Department University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Moreno\u2010Doc\u00f3n","sequence":"additional","affiliation":[{"name":"Virology Laboratory, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto M.","family":"Torres\u2010Cantero","sequence":"additional","affiliation":[{"name":"Preventive Medicine Department, University Hospital Virgen de la Arrixaca IMIB\u2010Pascual Parrilla, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Munoz Garcia","sequence":"additional","affiliation":[{"name":"IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Serrano","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hospital La Laguna  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Iacobelli","sequence":"additional","affiliation":[{"name":"Techitra S.R.L.  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Carlo\u2010Stella","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8582-920X","authenticated-orcid":false,"given":"Lee\u2010Jen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-8865","authenticated-orcid":false,"given":"Paul G.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute, Jerome Lipper Center for Multiple Myeloma Research, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9080-1466","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Moraleda","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplant and Cellular Therapy Unit, University Hospital Virgen de la Arrixaca, IMIB\u2010Pascual Parrilla University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201040727\u2010z"},{"key":"e_1_2_12_3_1","unstructured":"World Health Organization \u201cCoronavirus Disease (COVID\u201019) \u201d2023 accessed September 17 2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/coronavirus\u2010disease\u2010(covid\u201019)."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30566\u20103"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(20)30370\u20102"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102537"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010023\u201009162\u20108"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00399\u201020"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa481"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010025\u201011001\u20106"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.06.006"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028700"},{"key":"e_1_2_12_15_1","unstructured":"Red Nacional de Vigilancia Epidemiol\u00f3gica (RENAVE) \u201cInforme sobre la situaci\u00f3n de COVID\u201019 en Espa\u00f1a: Informe COVID\u201019 n\u00b0 15 25 de marzo de 2020 \u201d2020 accessed August 12 2025 https:\/\/cne.isciii.es\/documents\/d\/cne\/informe\u2010n\u201015\u2010situacion\u2010de\u2010covid\u201019\u2010en\u2010espana\u2010a\u201025\u2010marzo\u2010de\u20102020\u2010pdf."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010021\u201000536\u20109"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17240"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557\u2010021\u201007207\u2010w"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa230"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(20)30216\u20107"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa623"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102020\u2010142311"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u20100343\u20100"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30937\u20105"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm.2020.03.126"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.07.012"},{"key":"e_1_2_12_28_1","unstructured":"Gentium Srl \u201cDefitelio: EPAR\u2014Product Information \u201d2023 May accessed March 10 2025 https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/defitelio\u2010epar\u2010product\u2010information_en.pdf."},{"key":"e_1_2_12_29_1","unstructured":"Jazz Pharmaceuticals Inc \u201cDefitelio (Defibrotide Sodium) Injection for Intravenous Use\u2014Prescribing Information \u201d2022 December 2022 accessed October 17 2024 https:\/\/defitelio.com\/dosing\u2010and\u2010administration\/index."},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15434"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.03.046"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.285345"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.284793"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2021.1944101"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15071004"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017008375"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22240"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001282"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2007764"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20\u20104044"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201160"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2217\/ijh\u20102017\u20100015"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15088"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.262"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201004\u2010149682"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(20)30483\u20107"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2024.101218"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.70214","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:21:42Z","timestamp":1788510102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ejh.70214"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70214","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"2026-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}