{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:13:25Z","timestamp":1788513205915,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This cross\u2010sectional study evaluated the 12\u2010lead electrocardiogram (ECG) corrected QT (QTc) interval as an accessible marker for organ\u2010specific iron burden in adult patients with transfusion\u2010dependent thalassemia (TDT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We considered 273 adult TDT patients (37.48\u2009\u00b1\u20098.75\u2009years; 53.8% females), enrolled in the Extension\u2010Myocardial Iron Overload in Thalassemia Network. All patients underwent magnetic resonance imaging (MRI) for the quantification of hepatic, pancreatic, and myocardial iron ( technique) and the assessment of biventricular size and function, alongside a standard ECG within 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      QTc interval showed a significant negative correlation with pancreatic  (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.220;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and cardiac  (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u2009\u22120.201;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). A QTc\u2009&gt;\u2009425\u2009ms predicted myocardial iron overload (MIO; \u2009&lt;\u200920\u2009ms). A significant stepwise prolongation of the QTc interval was observed across groups: no iron overload (405.45\u2009ms), isolated pancreatic siderosis (421.76\u2009ms), and combined pancreatic\/myocardial siderosis (433.01\u2009ms) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). In patients without MIO, a QTc\u2009&gt;\u2009416\u2009ms predicted pancreatic siderosis (\u2009&lt;\u200926\u2009ms) and a multivariable regression analysis confirmed pancreatic iron, female sex, and splenectomy as independent predictors of QTc duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The QTc interval may serve as an early \u201cmetabolic sensor\u201d of multi\u2010organ iron toxicity. A QTc\u2009&gt;\u2009416\u2009ms is associated with pancreatic siderosis and possible cardiac risk before MRI detects cardiac iron. While QTc alone is unlikely to be sufficient for individual patient risk stratification, this inexpensive and widely available parameter may help inform decisions regarding advanced imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70242","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:44:31Z","timestamp":1781570671000},"page":"1026-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic Iron Overload Is Associated With Early\n                    <scp>QTc<\/scp>\n                    Prolongation Before Myocardial Iron Deposition in Transfusion\u2010Dependent Thalassemia"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-8585","authenticated-orcid":false,"given":"Antonella","family":"Meloni","sequence":"first","affiliation":[{"name":"Bioengineering Unit Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pistoia","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Ricerca Clinica Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovan Battista","family":"Ruffo","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Ematologia con Talassemia Azienda di Rilievo Nazionale ad Alta Specializzazione Civico \u201cBenfratelli\u2010Di Cristina\u201d  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Longo","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Talassemie ed Emoglobinopatie Azienda Ospedaliero\u2010Universitaria Arcispedale S. Anna  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamaria","family":"Rosso","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Talassemie ed Emoglobinopatie Azienda Ospedaliero\u2010Universitaria Policlinico G. Rodolico\u2010San Marco  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Rossi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Ematologia Ospedale di Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Messina","sequence":"additional","affiliation":[{"name":"Centro Microcitemie Grande Ospedale Metropolitano \u201cBianchi\u2010Melacrino\u2010Morelli\u201d  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Peritore","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa di Radiologia Azienda di Rilievo Nazionale ad Alta Specializzazione Civico \u201cBenfratelli\u2010Di Cristina\u201d  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Zerbini","sequence":"additional","affiliation":[{"name":"Diagnostica per Immagini e Radiologia Interventistica Ospedale del Delta  Lagosanto Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"Vallone","sequence":"additional","affiliation":[{"name":"Reparto di Radiologia Azienda Ospedaliera \u201cGaribaldi\u201d Presidio Ospedaliero Nesima  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Fina","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Diagnostica per Immagini Ospedale \u201cSandro Pertini\u201d  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Positano","sequence":"additional","affiliation":[{"name":"Bioengineering Unit Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Barison","sequence":"additional","affiliation":[{"name":"Cardiology and Cardiovascular Medicine Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Guidelines for the Management of Transfusion\u2010Dependent \u03b2\u2010Thalassaemia (5th Edition \u2013 2025)","author":"Taher A. T.","year":"2025"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"51","article-title":"The Regulation of Iron Absorption and Homeostasis","volume":"37","author":"Wallace D. 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