{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:13:16Z","timestamp":1788513196737,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100032203","name":"Danish Data Science Academy","doi-asserted-by":"publisher","award":["2023\u20101210"],"award-info":[{"award-number":["2023\u20101210"]}],"id":[{"id":"10.13039\/100032203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bloodstream infections remain a major cause of mortality among cancer patients. Pathogen surveillance and risk stratification tools are key to improved management. This study describes trends in causative pathogens and explores risk factors for positive blood cultures (PBCs) and post\u2010infection mortality in cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a cohort study of patients diagnosed with a B\u2010cell malignancy in the North Denmark Region between 2013 and 2022, linking cancer registry data to health records. Causative pathogens were described. LASSO regression was used to select variables associated with PBCs and post\u2010infection mortality. Odds ratios were estimated by univariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1592 patients with B\u2010cell malignancies, 341 patients (21.4%) had at least one PBC, yielding 484 PBCs. We observed a shift from Gram\u2010positive to Gram\u2010negative dominance, driven by an increased frequency of the most common pathogen\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Escherichia coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      (24.8%). Patients with neutropenia, elevated CRP, sepsis, hypotension, or kidney failure had a higher risk of a PBC. Advanced age, kidney failure, and sepsis were all associated with 30\u2010 and 90\u2010day post\u2010infection mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Routinely available parameters obtained at time of admission were associated with blood culture positivity and mortality. Our findings support the rationale for developing predictive models to individualise infection management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70246","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:49:58Z","timestamp":1781920198000},"page":"1061-1071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors of Blood Culture Positivity and Mortality in Bloodstream Infections: A Population\u2010Based Study of Patients With B\u2010Cell Malignancies"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0807-9352","authenticated-orcid":false,"given":"Mathias Holmsgaard","family":"Eskesen","sequence":"first","affiliation":[{"name":"Department of Oncology, Clinical Cancer Research Centre Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg\u00a0University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3879-1950","authenticated-orcid":false,"given":"Alexander Djupnes","family":"Fuglkj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Materials and Production Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-380X","authenticated-orcid":false,"given":"Tarec Christoffer","family":"El\u2010Galaly","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Haematology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-0523","authenticated-orcid":false,"given":"Paw","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg\u00a0University  Aalborg Denmark"},{"name":"Department of Haematology, Clinical Cancer Research Centre Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-2741","authenticated-orcid":false,"given":"Izabela Ewa","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Materials and Production Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-976X","authenticated-orcid":false,"given":"Laurids \u00d8stergaard","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Clinical Cancer Research Centre Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg\u00a0University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1119-4782","authenticated-orcid":false,"given":"Mikkel Runason","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Centre Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Mathematical Sciences Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-7999","authenticated-orcid":false,"given":"Kirstine Kobber\u00f8e","family":"S\u00f8gaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg\u00a0University  Aalborg Denmark"},{"name":"Department of Clinical Microbiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/go\u201024\u201000344"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.285645"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.70015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010024\u201005619\u2010w"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12813"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010018\u20100316\u20105"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.03.022"},{"key":"e_1_2_11_9_1","unstructured":"European Centre for Disease Prevention and Control (ECDC) \u201cSurveillance Atlas of Infectious Diseases [Internet]. 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