{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:51:19Z","timestamp":1791366679839,"version":"4.3.1"},"reference-count":159,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020912","name":"King Faisal University","doi-asserted-by":"publisher","award":["KFU263303"],"award-info":[{"award-number":["KFU263303"]}],"id":[{"id":"10.13039\/501100020912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The ubiquitous human gamma\u2010herpesvirus Epstein\u2013Barr virus (EBV) infects over 90% of adults globally and was the first human virus identified with oncogenic potential. EBV enters a lifelong persistence in the host via a finely regulated life\u2010cycle comprising primary infection, latency and lytic reactivation. Within infected B\u2010cells and epithelial cells, EBV encodes a distinct repertoire of microRNAs (miRNAs), primarily from the BART (BamHI A rightward transcript) and BHRF1 (BamHI H rightward open reading frame) clusters, which play pivotal roles in modulating both viral and host gene expression. These viral miRNAs contribute to key oncogenic processes: by dampening apoptotic responses (e.g., via targeting PUMA, Bim, and PTEN), promoting proliferation of latently\u2010infected B\u2010cells, inhibiting host immune responses (e.g., via down\u2010regulation of CXCL\u201011 by miR\u2010BHRF1\u20103), and promoting epithelial\u2010mesenchymal transition (EMT) and metastasis through modulation of E\u2010cadherin and other adhesion molecules. In human lymphomas, such as Burkitt lymphoma, Hodgkin lymphoma, and EBV\u2010positive diffuse large B\u2010cell lymphoma, the interplay of latent viral gene expression, miRNA\u2010mediated regulatory networks, and host microenvironmental factors underlies malignant transformation and disease progression. Emerging evidence also supports the utility of EBV\u2010encoded miRNAs as diagnostic and prognostic biomarkers in EBV\u2010associated cancers. Importantly, therapeutic strategies aimed at interrupting viral miRNA function, restoring host tumor\u2010suppressor pathways, and re\u2010sensitizing tumor cells to immune surveillance hold promise. This review synthesizes current mechanistic insights into EBV\u2010encoded miRNAs in oncogenesis, elaborates on their roles in lymphoma pathogenesis, and evaluates the translational potential of miRNA\u2010targeted therapies in EBV\u2010associated malignancies.<\/jats:p>","DOI":"10.1111\/ejh.70249","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T22:45:51Z","timestamp":1782686751000},"page":"1104-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epstein\u2010Barr Virus\n                    <scp>MicroRNAs<\/scp>\n                    as Key Regulators of Lymphoma Pathogenesis: Immune Evasion Mechanisms and Therapeutic Opportunities"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-3150","authenticated-orcid":false,"given":"Rasha","family":"Abu\u2010Khudir","sequence":"first","affiliation":[{"name":"Department of Chemistry College of Science, King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-7096","authenticated-orcid":false,"given":"Ahmed S.","family":"Doghish","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys) Al\u2010Azhar University  Cairo Egypt"},{"name":"Department of Biochemistry Faculty of Pharmacy, Badr University in Cairo (BUC)  Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-3683","authenticated-orcid":false,"given":"Hend H.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Badr University in Cairo  Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal I.","family":"Rizk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy and Drug Technology, Egyptian Chinese University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidy Adel","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology Badr University in Cairo (BUC)  Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma Zaki","family":"Fayez","sequence":"additional","affiliation":[{"name":"Molecular Biology and Biotechnology Department School of Biotechnology, Badr University in Cairo  Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Ashraf","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Badr University in Cairo  Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayatallah","family":"Elgohary","sequence":"additional","affiliation":[{"name":"Biotechnology Department Faculty of Biotechnology, October University for Modern Sciences and Arts  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hager Nasser","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology School of Biotechnology, Badr University in Cairo  Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa Mahmoud","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Molecular Biology and Biotechnology Department School of Biotechnology, Badr University in Cairo  Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-9609","authenticated-orcid":false,"given":"Osama A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Medicine, University of Bisha  Bisha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-5035","authenticated-orcid":false,"given":"Sherif S.","family":"Abdel Mageed","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department Faculty of Pharmacy, Badr University in Cairo (BUC)  Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-4470","authenticated-orcid":false,"given":"Rabab S.","family":"Hamad","sequence":"additional","affiliation":[{"name":"Biological Sciences Department College of Science, King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-9020","authenticated-orcid":false,"given":"Reda M.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Molecular Biology and Biotechnology Department School of Biotechnology, Badr University in Cairo  Badr City Egypt"},{"name":"Zoology and Entomology Department Faculty of Science, Capital University  Helwan Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-023-02187-9"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-316745"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.08.026"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-025-01388-9"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-026-06638-w"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.galenos.2025.2025-3-60"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-025-01730-7"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-025-01309-8"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70907"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122950"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70119"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.107646"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2014.04.003"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.01.006"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00281-13"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001063"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.71"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072581"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4448"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-015-3592-5"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131013737"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/594681"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.01.014"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm1080"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406136111"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005405"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.285"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13432"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8353"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.27488"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111824"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.5.2689-2697.1992"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26823"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.84"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10060167"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01793-3"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3331"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-12029-3"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1289313"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032015"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1452"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0249-7"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.4236\/jbm.2022.105012"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050991"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2010.02533.x"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1261-7"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.11.001"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-007-9013-8"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020023"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00367"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.667968"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01495-21"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2012.05.005"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.204"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479749"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200312"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501605"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.12.024"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5126"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00530-17"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160248"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002484"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605884113"},{"issue":"3","key":"e_1_2_17_68_1","first-page":"2887","article-title":"Epstein\u2013Barr Virus\u2010Encoded microRNA BART7 Downregulates Major Histocompatibility Complex Class I Chain\u2010Related Peptide A and Reduces the Cytotoxicity of Natural Killer Cells to Nasopharyngeal Carcinoma","volume":"16","author":"Wong T. S.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01667-16"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9050353"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-020-01059-3"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004561"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.07.002"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4237"},{"issue":"8","key":"e_1_2_17_75_1","first-page":"3201","article-title":"Overexpression of Epstein\u2013Barr Virus\u2010Encoded microRNA\u2010BART7 in Undifferentiated Nasopharyngeal Carcinoma","volume":"32","author":"Chan J. Y.\u2010W.","year":"2012","journal-title":"Anticancer Research"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6155"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3046"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28007"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5217039"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24863"},{"key":"e_1_2_17_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03639-14"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402055"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.08.001"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.10.023"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02794-15"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.01.028"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.36595"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-016-0602-7"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03159-12"},{"key":"e_1_2_17_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-016-3109-z"},{"key":"e_1_2_17_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.18"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000039RR"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027271"},{"issue":"1","key":"e_1_2_17_94_1","first-page":"73","article-title":"Epstein\u2013Barr Virus\u2010Associated Gastric Carcinoma and Epstein\u2013Barr Virus Infection of the Stomach","volume":"71","author":"Fukayama M.","year":"1994","journal-title":"Laboratory Investigation; a Journal of Technical Methods and Pathology"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.30099"},{"key":"e_1_2_17_96_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9170"},{"key":"e_1_2_17_97_1","doi-asserted-by":"crossref","unstructured":"Y. Y.Yeo H.Qiu Y.Bai et\u00a0al. \u201cEpstein\u2013Barr Virus Orchestrates Spatial Reorganization and Immunomodulation Within the Classic Hodgkin Lymphoma Tumor Microenvironment \u201d(2024) bioRxiv: The Preprint Server for Biology.","DOI":"10.1101\/2024.03.05.583586"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125592"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011506"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-00410-x"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.24562"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1631258"},{"key":"e_1_2_17_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28479-2"},{"key":"e_1_2_17_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-026-02999-y"},{"key":"e_1_2_17_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.878953"},{"key":"e_1_2_17_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omton.2024.200814"},{"key":"e_1_2_17_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02069-w"},{"key":"e_1_2_17_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-020-00307-6"},{"key":"e_1_2_17_109_1","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00093\u201021"},{"key":"e_1_2_17_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.03.008"},{"key":"e_1_2_17_111_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6173"},{"key":"e_1_2_17_112_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.897306"},{"key":"e_1_2_17_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12027"},{"key":"e_1_2_17_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.01.003"},{"key":"e_1_2_17_115_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2019.457"},{"key":"e_1_2_17_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47028-5"},{"key":"e_1_2_17_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-024-00615-1"},{"key":"e_1_2_17_118_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.42498"},{"key":"e_1_2_17_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009217"},{"key":"e_1_2_17_120_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/516047"},{"key":"e_1_2_17_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcvp.2023.100171"},{"key":"e_1_2_17_122_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000889"},{"key":"e_1_2_17_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-020-00292-w"},{"key":"e_1_2_17_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00964-w"},{"key":"e_1_2_17_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16203537"},{"key":"e_1_2_17_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.02.016"},{"key":"e_1_2_17_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041168"},{"key":"e_1_2_17_128_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000568"},{"key":"e_1_2_17_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17172929"},{"key":"e_1_2_17_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.03.003"},{"key":"e_1_2_17_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1852473"},{"key":"e_1_2_17_132_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0334"},{"key":"e_1_2_17_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2019.09.005"},{"key":"e_1_2_17_134_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312916"},{"key":"e_1_2_17_135_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341395"},{"key":"e_1_2_17_136_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014154"},{"key":"e_1_2_17_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.45"},{"key":"e_1_2_17_138_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.28673"},{"key":"e_1_2_17_139_1","doi-asserted-by":"crossref","unstructured":"X.Wang H.Huang andK. H.Young \u201cThe PTEN Tumor Suppressor Gene and Its Role in Lymphoma Pathogenesis \u201d(2015) 1945\u20134589 (Electronic).","DOI":"10.18632\/aging.100855"},{"key":"e_1_2_17_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020144"},{"key":"e_1_2_17_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-03893-7"},{"key":"e_1_2_17_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-025-01737-4"},{"issue":"5","key":"e_1_2_17_143_1","first-page":"4489","article-title":"MicroRNA\u201021 Regulates the Viability and Apoptosis of Diffuse Large B\u2010Cell Lymphoma Cells by Upregulating B Cell Lymphoma\u20102","volume":"14","author":"Liu K.","year":"2017","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_17_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2012.1"},{"key":"e_1_2_17_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2013.49"},{"key":"e_1_2_17_146_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-358382"},{"key":"e_1_2_17_147_1","doi-asserted-by":"publisher","DOI":"10.1177\/1177271918806840"},{"key":"e_1_2_17_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00936"},{"key":"e_1_2_17_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051229"},{"key":"e_1_2_17_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-014-1368-z"},{"key":"e_1_2_17_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.08.020"},{"key":"e_1_2_17_152_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-402784"},{"key":"e_1_2_17_153_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3831"},{"key":"e_1_2_17_154_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042193"},{"key":"e_1_2_17_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1350-9"},{"key":"e_1_2_17_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2022.101260"},{"key":"e_1_2_17_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.246"},{"key":"e_1_2_17_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1352805"},{"key":"e_1_2_17_159_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153909"},{"key":"e_1_2_17_160_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266893"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.70249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:04:20Z","timestamp":1791363860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":159,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/ejh.70249"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70249","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]},"assertion":[{"value":"2026-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}