{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:51:13Z","timestamp":1791366673781,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Myeloproliferative neoplasms (MPNs) are associated with increased thrombosis risk, and earlier identification is essential to reduce preventable complications. We investigated whether platelet counts during pregnancy were higher in women diagnosed with MPN after pregnancy than in controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nested case\u2013control study of pregnant women in two Danish regions between 2010 and 2017 using registry and laboratory data. The primary exposure was platelet counts during pregnancy, and the primary outcome was a subsequent MPN diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 49 cases with subsequent MPN, and 979 matched controls. Cases had significantly higher platelet counts (\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L) during pregnancy (325 (IQR 199\u2013419) vs. 219 (IQR 183\u2013254),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and platelet counts &gt;\u2009400 occurred in 29% of cases versus 2% of controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Adjusted models showed an estimated 85 higher platelet count in cases, and platelet counts &gt;\u2009400 during pregnancy were associated with an 18\u2010fold increased odds ratio (95% CI: 6\u201361) for later MPN. MPN status was strongly associated with higher platelet counts before, during, and after pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated platelet counts during pregnancy are strongly associated with subsequent MPN, suggesting that routine prenatal platelet counts may enable early identification of women at risk of MPN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70257","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:31:37Z","timestamp":1782790297000},"page":"1228-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet Counts During Pregnancy as Predictor of Subsequent Myeloproliferative Neoplasm"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9247-4833","authenticated-orcid":false,"given":"Freja Rueholm","family":"Klok","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine Jeong","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Kranker","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynecology Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibe","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ellervik","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Laboratory Medicine Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik L\u00f8vendahl","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Carl","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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