{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:51:17Z","timestamp":1791366677438,"version":"4.3.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81873444"],"award-info":[{"award-number":["No.81873444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82070213"],"award-info":[{"award-number":["No.82070213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82370196"],"award-info":[{"award-number":["No.82370196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873444"],"award-info":[{"award-number":["81873444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070213"],"award-info":[{"award-number":["82070213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370196"],"award-info":[{"award-number":["82370196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the feasibility and safety of venetoclax as a cytoreductive strategy during induction therapy in newly diagnosed acute promyelocytic leukemia (APL), and to provide an exploratory description of its early efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a single\u2010center retrospective analysis including 29 patients newly diagnosed with APL between January 2023 and December 2025. All patients received induction therapy with all\u2010trans retinoic acid (ATRA) plus arsenic trioxide (ATO) and were treated with different cytoreduction strategies based on clinical decision\u2010making: venetoclax group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916) or conventional cytoreduction group (hydroxyurea\u2009\u00b1\u2009anthracycline,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportion of hematologic complete recovery (HCR) at Day 28 was significantly higher in the venetoclax group than in the conventional group (93.75% vs. 46.15%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). The median time to HCR was shorter in the venetoclax group (26 vs. 28\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The median time to molecular complete remission (MCR) was also shorter (92 vs. 110\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). In addition, the venetoclax group required significantly fewer red blood cell and platelet transfusions and had a shorter duration of hospitalization. There was no statistically significant difference in the incidence of differentiation syndrome (DS) between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Venetoclax appears to be a feasible and safe cytoreductive option during induction therapy in APL and may be associated with faster hematologic recovery. These findings require further validation in prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70264","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:00:47Z","timestamp":1783983647000},"page":"1258-1264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and Safety of Venetoclax for Cytoreduction During Induction Therapy in Newly Diagnosed Acute Promyelocytic Leukemia"],"prefix":"10.1111","volume":"117","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hematology Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital  Chengdu City Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital  Chengdu City Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-6774","authenticated-orcid":false,"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010025\u201001336\u20103"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19119"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.592996"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.12.013"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100233\u20101"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201007623\u20108"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109182"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0025"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18061"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23671"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BS9.0000000000000111"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845\u2010024\u201003751\u20100"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.005910"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00554.2015"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.70264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:04:26Z","timestamp":1791363866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/ejh.70264"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70264","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"2026-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}