{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:51:14Z","timestamp":1791366674676,"version":"4.3.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Somatic mutations in the MAPK signaling pathway are frequently identified at AML diagnosis; however, their impact on treatment resistance and long\u2010term survival remains unclear. We conducted a retrospective study of patients with newly diagnosed MAPK\u2010mutated AML seen at the University of Iowa Health Care. The endpoints were overall survival (OS), composite complete remission (CRc) following induction therapy, and relapse\u2010free survival (RFS). Logistic and Cox regression models were used. Seventy\u2010four patients were included and 62 were induction eligible. Of the 62 patients receiving treatment, intensive induction was administered in 52.7%. The estimated 5\u2010year OS was 28.9%. On multivariable analysis, European LeukemiaNet 2022 adverse risk (hazard ratio [HR]: 3.56, 95% confident interval [CI]: 1.52\u20138.32) and\n                    <jats:italic>KRAS<\/jats:italic>\n                    mutation (HR: 2.14, 95% CI: 1.10\u20134.17) conferred inferior OS. Abnormal karyotype (odds ratio [OR]: 0.25, 95% CI: 0.07\u20130.89) and increasing age (OR: 0.97, 95% CI: 0.94\u20130.99) were associated with decreased odds of achieving a CRc. The median RFS after achieving a CRc was 13.3\u2009months. We found that\n                    <jats:italic>KRAS<\/jats:italic>\n                    mutation conferred an inferior effect on OS and RFS but not CRc. These findings suggest that\n                    <jats:italic>KRAS<\/jats:italic>\n                    mutations may confer adverse prognostic significance and warrant validation in larger, multicenter cohorts.\n                  <\/jats:p>","DOI":"10.1111\/ejh.70270","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:37:13Z","timestamp":1784943433000},"page":"1318-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>KRAS<\/i>\n                    Mutations Predict Inferior Post\u2010Remission Outcomes in Newly Diagnosed Acute Myeloid Leukemia With\n                    <scp>MAPK<\/scp>\n                    Pathway Mutations"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4385-6883","authenticated-orcid":false,"given":"Kensuke","family":"Takaoka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Iowa Health Care  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mott","sequence":"additional","affiliation":[{"name":"University of Iowa Health Care Holden Comprehensive Cancer Center  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratdanai","family":"Yodsuwan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa Health Care  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-8674","authenticated-orcid":false,"given":"Sakditad","family":"Saowapa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa Health Care  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasawee","family":"Tanariyakul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa Health Care  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0408","authenticated-orcid":false,"given":"Chalothorn","family":"Wannaphut","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Hawai'i John A. Burns School of Medicine  Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5038-7093","authenticated-orcid":false,"given":"Kittika","family":"Poonsombudlert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa Health Care  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406184"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-0867"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26146"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-378596"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516192"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2190432"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025409"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00108-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.004"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003988"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1453"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409405"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004315"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.70270","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.70270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:03:50Z","timestamp":1791363830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.70270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/ejh.70270"],"URL":"https:\/\/doi.org\/10.1111\/ejh.70270","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"2026-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}