{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:51:14Z","timestamp":1791366674082,"version":"4.3.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute myeloid leukaemia (AML) in older or unfit patients is commonly treated with hypomethylating agents (HMA) plus venetoclax (VEN), but prolonged VEN exposure often causes substantial haematological toxicity. We retrospectively analysed 61 elderly AML patients treated with HMA\u2009+\u2009VEN for 7 (7d), 14 (14d) or &gt;\u200914\u2009days (&gt;\u200914d) per cycle. Best overall response rate was 76% and did not differ significantly between schedules (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.38). Median overall survival (OS) was numerically longer with 7d (28.4\u2009months) than with 14d (11.4\u2009months) or &gt;\u200914d (6.7\u2009months), although unadjusted differences were not significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.23). At cycle level, the 7d schedule was associated with fewer infections and more complication\u2010free cycles than both longer schedules, while bleeding events were similar. Grade 4 cytopenias and platelet transfusion requirements were also lower with 7d. In an adjusted Cox model, prior HMA exposure, non\u2010favourable ELN 2024 risk and age\u2009\u2265\u200975\u2009years were associated with inferior OS, whereas the 7d schedule remained associated with improved OS versus &gt;\u200914d (HR 0.33,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). Higher recent grade 4 neutropenia burden was independently associated with inferior OS. These findings suggest that abbreviated VEN exposure may improve tolerability without clear loss of efficacy in AML patients ineligible for intensive chemotherapy.\n                  <\/jats:p>","DOI":"10.1111\/ejh.70279","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:28:49Z","timestamp":1785457729000},"page":"1358-1368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dose\u2010Adjusted Treatment With 7\u2010Day Venetoclax Plus Azacitidine or Decitabine in Patients With Acute Myeloid Leukaemia"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-037X","authenticated-orcid":false,"given":"Laurenz","family":"Steiner","sequence":"first","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6014-4470","authenticated-orcid":false,"given":"Lina S.","family":"Silva\u2010Bermudez","sequence":"additional","affiliation":[{"name":"German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2010Hessen, Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Ghazal","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Abba","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Gerhards","sequence":"additional","affiliation":[{"name":"Medical Faculty Mannheim, Institute for Clinical Chemistry Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Metzgeroth","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Fabarius","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kreil","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-9606","authenticated-orcid":false,"given":"Nanni","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-2870","authenticated-orcid":false,"given":"Patrick","family":"Wuchter","sequence":"additional","affiliation":[{"name":"German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2010Hessen, Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf\u2010Karsten","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3531-534X","authenticated-orcid":false,"given":"Alexander","family":"Streuer","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2025.101503"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.70028"},{"key":"e_1_2_12_5_1","volume-title":"VENCLEXTA U.S. Food and Drug Administration","author":"U.S. Food and Drug Administration","year":"2019"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2020.1843752"},{"issue":"1","key":"e_1_2_12_7_1","first-page":"285","article-title":"Azacitidine in Combination With Shortened Venetoclax Treatment Cycles in Patients With Acute Myeloid Leukemia","volume":"104","author":"Fleischmann M.","year":"2025","journal-title":"Annals of 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