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This variant encodes a proline to leucine substitution at residue 251 in the long isoform (P251L) and residue 205 in the short isoform (P205L) of TACI. Using HEK293 cells, NF\u2010\u03baB signalling of the variant and wild type forms of TACI was measured by using an NF\u2010\u03baB\u2010luciferase reporter assay and by quantifying NF\u2010\u03baB p65 subcellular localisation. The TACI P205L variant showed substantially reduced NF\u2010\u03baB activity compared to the wild type version of the short isoform. This result suggests an indirect effect of TACI P205L on the increased risk of myeloma.\n                  <\/jats:p>","DOI":"10.1111\/ejh.70283","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:45:56Z","timestamp":1785829556000},"page":"1391-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Myeloma Risk Variant of\n                    <scp>\n                      <i>TNFRSF13B<\/i>\n                    <\/scp>\n                    Shows Reduced\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Signalling Activity in\n                    <scp>HEK293<\/scp>\n                    Cells"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9320-1877","authenticated-orcid":false,"given":"Richard Muyan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie L.","family":"Ludgate","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E.","family":"Cunliffe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8873-9423","authenticated-orcid":false,"given":"Ali G.","family":"Dohan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-0025","authenticated-orcid":false,"given":"Ian M.","family":"Morison","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","first-page":"e502","article-title":"A Journey Through Myeloma Evolution: From the Normal Plasma Cell to Disease Complexity","volume":"4","author":"Da Via M. 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