{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:21:04Z","timestamp":1787656864398,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["222017Pj"],"award-info":[{"award-number":["222017Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007232","name":"Radiumhemmets Forskningsfonder","doi-asserted-by":"publisher","award":["241142"],"award-info":[{"award-number":["241142"]}],"id":[{"id":"10.13039\/501100007232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032253","name":"Nordic Cancer Union","doi-asserted-by":"publisher","award":["A16008"],"award-info":[{"award-number":["A16008"]}],"id":[{"id":"10.13039\/100032253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032253","name":"Nordic Cancer Union","doi-asserted-by":"publisher","award":["A16094"],"award-info":[{"award-number":["A16094"]}],"id":[{"id":"10.13039\/100032253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det f\u00f6r h\u00e4lsa, arbetsliv och v\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2024\u201001521"],"award-info":[{"award-number":["2024\u201001521"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Concerns about treatment\u2010related fertility impairment are common among young adult lymphoma survivors. Evidence on the impact of treatment for aggressive non\u2010Hodgkin lymphoma (NHL) on future childbearing is limited, although many individuals of reproductive age are affected. This matched cohort study identified male (18\u201352\u2009years) and female (18\u201340\u2009years) patients with aggressive NHL between 2007 and 2018 in Sweden and the south\u2010east health\u2010care region in Norway, and matched lymphoma\u2010free comparators. Adjusted hazard ratios (aHRs) comparing childbirth rates in patients treated with primary intensive chemoimmunotherapy (CIT) (e.g., R\u2010CHOEP and R\u2010DA\u2010EPOCH) to standard\u2010of\u2010care (R\u2010CHOP), and to comparators, were estimated using Cox regression. Among 1037 young survivors of aggressive NHL, childbirth rates did not differ significantly by treatment intensity (intensive vs. standard CIT) in females (aHR: 0.61, 95% CI: 0.32\u20131.13) or males (aHR: 1.20, 95% CI: 0.68\u20132.09), overall or when stratified by time since diagnosis (&lt;\u20093 and 3\u201310\u2009years). However, females treated with intensive CIT had lower childbirth rates than comparators during the first 3\u2009years after diagnosis (aHR: 0.52, 95% CI: 0.30\u20130.88), but not thereafter (aHR: 1.06, 95% CI: 0.57\u20131.96). A similar pattern was not seen in males. In Sweden, eight children (three with support from assisted reproductive techniques) were born after stem cell transplantation. In conclusion, childbirth rates did not differ by CIT intensity among survivors of aggressive NHL. Although rates were temporarily reduced in females during the treatment and recovery period after diagnosis, subsequent rates were similar to comparators. These findings provide reassurance, while highlighting the importance of early and ongoing fertility counseling.<\/jats:p>","DOI":"10.1111\/ejh.70303","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:41:36Z","timestamp":1787654496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Intensified Chemoimmunotherapy Regimens in Aggressive Non\u2010Hodgkin Lymphoma on Reproduction Patterns"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0254-5663","authenticated-orcid":false,"given":"Stefanie","family":"Antonilli","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marklund","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Division of Gynecology and Reproduction Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-8096","authenticated-orcid":false,"given":"Joshua","family":"Entrop","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Red Door Analytics AB  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-8183","authenticated-orcid":false,"given":"Caroline E.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-3041","authenticated-orcid":false,"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarec C.","family":"El\u2010Galaly","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Foss\u00e5","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-9428","authenticated-orcid":false,"given":"Harald","family":"Holte","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9832-4032","authenticated-orcid":false,"given":"Knut B.","family":"Smeland","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-0573","authenticated-orcid":false,"given":"Sandra","family":"Eloranta","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 Revision of the World Health Organization Classification of Lymphoid Neoplasms","volume":"127","author":"Swerdlow S. 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