{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:45:46Z","timestamp":1793148346944,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Baseline systemic inflammation has emerged as a determinant of outcome after CD19\u2010directed CAR\u2010T therapy. We evaluated the prognostic performance of the recently developed INFLAmmation MIXture Model (InflaMix) in an independent bicentric cohort of patients with large B\u2010cell lymphoma (LBCL) receiving commercial CAR\u2010T cells, focusing on treatment\u2010related toxicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 212 consecutive patients with relapsed\/refractory LBCL treated with axi\u2010cel, tisa\u2010cel, or liso\u2010cel between 2020 and 2026. Patients were classified according to the InflaMix inflammatory phenotype. Progression\u2010free survival (PFS), CAR\u2010T\u2010related toxicities, ICU admission, and concordance with CAR\u2010HEMATOTOX and mEASIX were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An inflammatory InflaMix phenotype was identified in 21% of patients and was associated with inferior PFS (12\u2010month PFS: 30% vs. 56%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). While overall grade 2\u20134 CRS and ICANS rates were comparable, inflammatory patients showed higher rates of grade 3\u20134 CRS (11.1% vs. 1.8%; OR 3.18) and ICU admission (24.4% vs. 5.6%; OR 3.00). No association with ICAHT was observed. Concordance was poor with CAR\u2010HEMATOTOX and moderate with mEASIX.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>InflaMix was externally validated as a predictor of inferior PFS, severe CRS, and ICU admission after CAR\u2010T therapy, and candidates as a practical tool for pre\u2010infusion risk stratification and as a complement to existing scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70307","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:44:36Z","timestamp":1787921076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>InflaMix<\/scp>\n                    Predicts Severe\n                    <scp>CRS<\/scp>\n                    ,\n                    <scp>ICU<\/scp>\n                    Admission, and Progression\u2010Free Survival After\n                    <scp>CAR<\/scp>\n                    \u2010T Therapy in\n                    <scp>LBCL<\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-916X","authenticated-orcid":false,"given":"Eugenio","family":"Galli","sequence":"first","affiliation":[{"name":"Department of Laboratory and Hematological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Mannina","sequence":"additional","affiliation":[{"name":"Department of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4766-2805","authenticated-orcid":false,"given":"Alessandro","family":"Corrente","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Radiologic and Hematologic Sciences Universit\u00e0 Cattolica del Sacro Cuore  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7738-997X","authenticated-orcid":false,"given":"Chiara","family":"De Philippis","sequence":"additional","affiliation":[{"name":"Department of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Pansini","sequence":"additional","affiliation":[{"name":"Department of Laboratory and Hematological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Hematology Section, Department of Radiologic and Hematologic Sciences Universit\u00e0 Cattolica del Sacro Cuore  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Viscovo","sequence":"additional","affiliation":[{"name":"Department of Laboratory and Hematological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Hematology Section, Department of Radiologic and Hematologic Sciences Universit\u00e0 Cattolica del Sacro Cuore  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-7197","authenticated-orcid":false,"given":"Stefan","family":"Hohaus","sequence":"additional","affiliation":[{"name":"Department of Laboratory and Hematological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Hematology Section, Department of Radiologic and Hematologic Sciences Universit\u00e0 Cattolica del Sacro Cuore  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-1587","authenticated-orcid":false,"given":"Patrizia","family":"Chiusolo","sequence":"additional","affiliation":[{"name":"Department of Laboratory and Hematological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Hematology Section, Department of Radiologic and Hematologic Sciences Universit\u00e0 Cattolica del Sacro Cuore  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-5298","authenticated-orcid":false,"given":"Federica","family":"Sor\u00e0","sequence":"additional","affiliation":[{"name":"Department of Laboratory and Hematological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Hematology Section, Department of Radiologic and Hematologic Sciences Universit\u00e0 Cattolica del Sacro Cuore  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bramanti","sequence":"additional","affiliation":[{"name":"Department of Hematology IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2426-3465","authenticated-orcid":false,"given":"Simona","family":"Sica","sequence":"additional","affiliation":[{"name":"Department of Laboratory and Hematological Sciences Fondazione Policlinico Universitario A. 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