{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:13:17Z","timestamp":1788315197551,"version":"build-2803163510"},"reference-count":104,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      mutation is a driver mutation in Philadelphia\u2010negative chronic myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and myelofibrosis. Recent studies have revealed a significant prevalence of\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      as clonal hematopoiesis of indeterminate potential (CHIP) in the general population, particularly in individuals over 50\u2009years. CHIP\u2010\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      carriers exhibit increased mortality, driven by cardiovascular diseases and cancer. Given the prothrombotic and inflammatory nature of\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      , we investigated its prevalence in patients with acute coronary syndrome (ACS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We screened 526 consecutive ACS patients for the\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      mutation using sensitive droplet digital PCR (ddPCR) and allele\u2010specific real\u2010time quantitative PCR (RQPCR). Clinical and laboratory data were analyzed to assess associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      mutation was detected in 6.1% (32\/526) of ACS patients, significantly higher than the general population prevalence (3.1%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      may contribute to ACS pathogenesis through prothrombotic and inflammatory mechanisms. Screening for\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      in high\u2010risk cardiovascular patients could identify individuals who may benefit from targeted therapies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70311","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:15:58Z","timestamp":1788311758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Prevalence of the\n                    <scp>\n                      <i>JAK2V617F<\/i>\n                    <\/scp>\n                    Mutation in Patients With Acute Coronary Syndrome"],"prefix":"10.1111","author":[{"given":"Balla","family":"Evelin","sequence":"first","affiliation":[{"name":"Somogy County Moritz Kaposi General Hospital  Kaposvar Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-3130","authenticated-orcid":false,"given":"Vorobcsuk","family":"Andras","sequence":"additional","affiliation":[{"name":"Somogy County Moritz Kaposi General Hospital  Kaposvar Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kovacs","family":"Eszter","sequence":"additional","affiliation":[{"name":"Somogy County Moritz Kaposi General Hospital  Kaposvar Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bela","family":"Kajtar","sequence":"additional","affiliation":[{"name":"University of P\u00e9cs Medical School  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herczeg","family":"Jozsef","sequence":"additional","affiliation":[{"name":"Somogy County Moritz Kaposi General Hospital  Kaposvar 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Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacza","family":"Agnes","sequence":"additional","affiliation":[{"name":"University of P\u00e9cs Medical School  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-7826","authenticated-orcid":false,"given":"Skov","family":"Vibe","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6767-0226","authenticated-orcid":false,"given":"Kj\u00e6r","family":"Lasse","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larsen","family":"Morten Kranker","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde 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