{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:55:53Z","timestamp":1790729753890,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>B\u2010cell maturation antigen (BCMA)\u2010targeted therapies have recently transformed the management of relapsed or refractory multiple myeloma (RRMM). This study aimed to evaluate their implementation and real\u2010world impact within EMMY, a French longitudinal cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients initiating a fourth or later line of therapy (L4+) between 2017 and 2023 across 73 centers were included. Temporal trends in treatment use were described. Outcomes, including progression\u2010free survival (PFS) and time to next treatment (TTNT), were compared between patients treated with BCMA\u2010targeted therapies and other regimens. Analyses were performed at the patient level and at the treatment\u2010line level. Safety data were not collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1362 patients treated in L4+, 294 (21.6%) received a BCMA\u2010targeted regimen. Use increased from 2.4% in 2019 to 52.0% in 2023, driven by bispecific antibodies. Outcomes improved over time, with median TTNT rising from 8.0\u2009months in 2017 to 12.1\u2009months in 2022, and median PFS from 7.2 to 9.3\u2009months. In L4, BCMA\u2010targeted therapies were associated with longer TTNT (21.7 vs. 9.3\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and PFS (13.4 vs. 7.9\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Similar trends were observed in later lines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BCMA\u2010targeted therapies were rapidly integrated into real\u2010world practice and were associated with improved outcomes in late\u2010line RRMM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70334","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:06:26Z","timestamp":1790726786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>BCMA<\/scp>\n                    Targeted Therapies and Their Impact on Outcomes in Relapsed or Refractory Multiple Myeloma: Results From the French\n                    <scp>EMMY<\/scp>\n                    Cohort"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5834-5318","authenticated-orcid":false,"given":"Titouan","family":"Cazaubiel","sequence":"first","affiliation":[{"name":"Service d'h\u00e9matologie et th\u00e9rapie cellulaire Hopital Haut Leveque, CHU Bordeaux  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2361-9669","authenticated-orcid":false,"given":"Olivier","family":"Decaux","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie clinique CHU de Rennes  Rennes France"},{"name":"MOBIDIC \u2010 Microenvironment and B\u2010Cells: Immunopathology, Cell Differentiation, and Cancer CHU Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-8689","authenticated-orcid":false,"given":"Aurore","family":"Perrot","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Institut Universitaire du Cancer de Toulouse\u2010Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Royer","sequence":"additional","affiliation":[{"name":"Service d'Immuno\u2010H\u00e9matologie H\u00f4pital Saint Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7455-5434","authenticated-orcid":false,"given":"Karim","family":"Belhadj\u2010Merzoug","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Fonctionnelle H\u00e9mopathies Lympho\u00efdes CHU Henri Mondor  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0460-0658","authenticated-orcid":false,"given":"Margaret","family":"Macro","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie H\u00f4pital Caen  Caen 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