{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:47:01Z","timestamp":1791974821331,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the impact of the time\u2010of\u2010day (daytime vs. nighttime) of the infusion of post\u2010transplantation cyclophosphamide (PTCy) on the occurrence of haemorrhagic cystitis (HC) in adult patients undergoing allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, single\u2010centre cohort study including adult allo\u2010HSCT between January 2014 and December 2022. All patients received PTCy at a dose of 50\u2009mg\/kg\/day for two consecutive days. Patients were classified according to the timing of the first PTCy dose: daytime (06:00\u201317:59) or nighttime (18:00\u201305:59). The primary endpoint was the incidence of Grade II\u2013IV HC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 178 patients were included. Grade II\u2013IV HC occurred in 16.4% and 31.2% of patients following daytime and nighttime administration, respectively (OR 2.31, 95% CI 0.97\u20135.49;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.079). After adjustment for potential confounders, nighttime administration was associated with higher odds of Grade II\u2013IV HC (adjusted OR 2.82, 95% CI 1.12\u20137.10;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). Grade III\u2013IV HC was more frequent following nighttime administration (4.8% vs. 15.6%; OR 3.68, 95% CI 1.09\u201312.45;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043). No significant differences were observed in transplant outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nighttime administration of PTCy was associated with a numerically higher incidence of Grade II\u2013IV HC, although the unadjusted primary analysis did not reach conventional statistical significance. This association was statistically significant after adjustment for potential confounders. No detectable differences in transplant outcomes were observed. These findings support prospective evaluation of chronomodulated PTCy administration as a simple, potentially modifiable strategy for reducing treatment\u2010related toxicity after allo\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.70336","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:03:33Z","timestamp":1791972213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between the Time of Day of Post\u2010Transplant Cyclophosphamide Administration and Haemorrhagic Cystitis After Allogeneic Haematopoietic Stem Cell Transplantation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6752-873X","authenticated-orcid":false,"given":"Maria\u2010Estela","family":"Moreno\u2010Martinez","sequence":"first","affiliation":[{"name":"Pharmacy Department Hospital de la Sant Creu i Sant Pau, IR\u2010Sant Pau  Barcelona 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Institutes, Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Gich","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health Department Hospital de la Santa Creu i Sant Pau, IR\u2010Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Paviglianiti","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital de la Sant Creu i Sant Pau, IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes, Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-7410","authenticated-orcid":false,"given":"Sara","family":"Redondo","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital de la Sant Creu i Sant Pau, IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes, Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Briones","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital de la Sant Creu i Sant Pau, IR\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes, Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-2231","authenticated-orcid":false,"given":"Anna","family":"Feliu","sequence":"additional","affiliation":[{"name":"Pharmacy Department Hospital de la Sant Creu i Sant Pau, IR\u2010Sant Pau  Barcelona Spain"},{"name":"School of Health Sciences Blanquerna University Ramon Llull  Barcelona 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